Active Research Funding FY2023
Oliver Adunka, MD 08/01/2020 – 07/31/2025 NIH/NIDCD U01DC018920
Clinical Utility of Residual Hearing in the Cochlear Implant Ear
Lauren Bakaletz, PhD 09/30/1999 – 03/31/2026 NIH/NIDCD R01DC003915
Determinants of H. influenzae Virulence in Otitis Media
Tendy Chiang, MD 07/16/2021 – 06/30/2026 NIH/NHLBI R01HL157039
Tissue-Engineered Trachea Composites for Long-Segment Airway Replacement
Thomas Cherpes, MD, DVM 07/01/2021 – 05/31/2023 NIH/NIDCD R01HD094634
Estrogen Reverses Progestin-mediated Loss of Genital Mucosal Barrier Function
Shuman He, MD, PhD 04/01/2023 – 03/31/2028 NIH/NIDCD R21DC019458
Auditory Neural Function in Implanted Patients with Usher Syndrome
Shuman He, MD, PhD 03/01/2020 – 02/28/2025 NIH/NIDCD R01DC018044
Encoding Temporal Fine Structure for Cochlear Implants
Shuman He, MD, PhD 09/12/2019 – 08/31/2024 NIH/NIDCD R01DC018701
Music Appreciation after Cochlear Implantation
Shuman He, MD, PhD 04/01/2019 – 03/31/2024 NIH/NIDCD R01DC017846
Neural Encoding and Auditory Processing of Electrical Stimulation in Pediatric Cochlear Implant Users
Daniel Merfeld, PhD 09/01/2021 – 08/31/2026 NIH/NIA R01AG073113
Towards healthy aging: Quantifying vestibular contributors to age-related changes in balance and fall risk
Daniel Merfeld, PhD 09/12/2020 – 03/23/2023 NIH/NIBIB R01EB029818
Moving MRI: Imaging a Moving Body with a Moving MRI Magnet
Yin Ren, MD, PhD 01/01/2023 – 12/31/2027 NIH/NIDCD K08DC020761
Engineering Protease Biomarkers to Guide Surgical Therapy for Vestibular Schwannoma and Neurofibromatosis Type 2
James Rocco, MD, PhD 03/28/2019 – 02/28/2025 NCI/NCTN UG1CA233331
OSU as a Network Lead Academic Participating Site for the NCI NCTN
James Rocco, MD, PhD 07/18/2022 – 06/30/2027 NCI/NCTN R01CA265975
Racial Differences in Immunogenetic Tumorigenesis of Head and Neck Squamous Cell Carcinoma
Andrew Wagner, MD 01/01/2023 – 12/31/2024 NIH/NIDCD K99ADC020759
Investigating Subthreshold Vestibular Stimulation as a Strategy for Rehabilitation in Individuals with Bilateral Vestibular Hypofunction
Ruili Xie, PhD 07/01/2022 – 06/30/2027 NIH/NIDCD R01DC016037
Auditory Nerve Synaptopathy and the Central Mechanisms Underlying Noise-induced Hearing Loss
Ruili Xie, PhD 09/19/2017 – 06/30/2023 NIH/NIDCD R56DC019093
Cellular Mechanisms of Age Related Hearing Loss
Kai Zhao, PhD 09/26/2022 – 07/31/2027 NIH/NIDCD R01DC020302
Novel Mechanisms and Therapeutic Approaches for Nasal Obstruction and Olfactory Losses
Kai Zhao, PhD 02/01/2023-01/31/2028 NIH/NIDCD R01DC020737
Short-term and Long-term Impact of COVID-19 on Multiple Sensory Systems
Oliver Adunka, MD 08/15/2019 – 08/14/2023 DOD
Cochlear Synaptopathy Using Electrocochleography
Eugene Chio, MD 10/26/2022 – 10/26/2024 Inspire
The Predictor Study: Assessing Diagnostic Predictors of Airway Collapse in Patients with Obstructive Sleep Apnea
Eugene Chio, MD 06/22/2018 – 06/21/2024 Inspire
Adherence and Outcome of Upper Airway Stimulation (UAS) for Obstructive Sleep Apnea (OSA) International Registry
Casey Curtis, MD 02/08/2020 – 02/17/2024 AstraZeneca
A Multicentre, Randomised, Double-blind, Parallel-group, Placebo controlled, 24-week Phase 3 Study with an Open-label Extension to Evaluate the Efficacy and Safety of Benralizumab in Patients with Hypereosinophilic Syndrome (HES)
Carrie Davenport, PhD 06/01/2022 – 05/31/2024 PCORI
Building Capacity for Engaging Families in Early Hearing Detection and Intervention Research
Vivian Kaul, MD 07/01/2022 – 06/30/2023 American Neurotology Society
Improving Patient Satisfaction and Quality of Life Outcomes for Cochlear Implant Patients through an Interactive Web and Mobile-Based Patient Education Platform
Daniel Merfeld, PhD 05/01/2023 – 04/30/2025 NAMRU-D
Vestibular Impacts on Human Behavior, Sleep, and Performance
Daniel Merfeld, PhD 05/01/2020 – 04/30/2025 Office of Naval Research
Identifying Adverse Modes via Human Machine Cybernetic Modeling
Daniel Merfeld, PhD 11/03/2022 – 01/17/2023 Soartech
Wing Instruction Spatial Disorientation Outcome Measure (WISDOM)
Daniel Merfeld, PhD 04/15/2019 – 04/14/2024 DOD
Evaluating a Portable Virtual-Reality (VR) Balance Test as a Vestibular Assessment Screen
Kyle VanKoevering, MD 10/13/2021 – 06/30/2023 NCI
Tissue Procurement Protocol for the Developmental Therapeutics Clinic
The Department of Otolaryngology – Head and Neck Surgery also continues to be a national leader in the exploration of ear, nose and throat, head and neck cancer, and human communication disorders through our active clinical trials.
Active Clinical Trials FY2023
Casey Curtis, MD and Christopher Brooks, MD – A Randomized, Double-Blind, Placebo-controlled Study to Investigate the Efficacy and Safety of Depemokimab in Adults with Hypereosinophilic Syndrome
Eugene Chio, MD – Multicenter Study to Assess the Safety and Effectiveness of the Genio™ Dual-sided Hypoglossal Nerve Stimulation System for the Treatment of Obstructive Sleep Apnea in Adult Subjects
Eugene Chio, MD – The PREDICTOR Study: Assessing Diagnostic Predictors of Airway Collapse in Patients With Obstructive Sleep Apnea
Sujith Baliga, MD – Randomized Phase II/III Trial of Radiation with High-Dose Cisplatin (100 MG/M2) Every Three Weeks Versus Radiation with Low-Dose Weekly Cisplatin (40 MG/M2) for Patients with Locoregionally Advanced Squamous Cell Carcinoma of the Head and Neck (SCCHN)
Priyanka Bhateja, MD – A Phase II/III Randomized Study of Maintenance Nivolumab versus Observation in Patients with Locally Advanced, Intermediate Risk HPV Positive OPSCC
Priyanka Bhateja, MD – Phase I Trial with Expansion Cohort of DNA-PK Inhibition and IMRT in Cisplatin-Ineligible Patients with Stage 3-4 Local-Regionally Advanced Head and Neck Squamous Cell Carcinoma (HNSCC)
Priyanka Bhateja, MD – A Phase II, Open-Label, Multi-Center Study of PDS0101 (R-DOTAP [Versamune®] + HPVmix) and Pembrolizumab (KEYTRUDA®) Combination Immunotherapy in Subjects with Recurrent and/or Metastatic Head and Neck Cancer and High-Risk Human Papillomavirus-16 (HPV16) Infection
Priyanka Bhateja, MD – A Phase II Study of ALX148 in Combination with Pembrolizumab and Chemotherapy in Patients with Advanced Head and Neck Squamous Cell Carcinoma (Aspen-04)
Priyanka Bhateja, MD – A Phase II Study of ALX148 in Combination with Pembrolizumab in Patients with Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-03)
Dukagjin Blakaj, MD, PhD – Birinapant and Intensity Modulated Re-Irradiation Therapy (IMRRT) for Locoregionally Recurrent Head and Neck Squamous Cell Carcinoma (HNSCC)
Dukagjin Blakaj, MD, PhD – HNSALV Trial: Combining Immunotherapy with Salvage Surgery and IORT for Treatment of Persistent/Recurrent Head and Neck Cancers
Dukagjin Blakaj, MD, PhD – Randomized Phase II/III Trial of Surgery and Postoperative Radiation Delivered with Concurrent Cisplatin Versus Docetaxel Versus Docetaxel and Cetuximab for High-Risk Squamous Cell Cancer of The Head And Neck
Dukagjin Blakaj, MD, PhD – Keystroke: A Randomized Phase II Study of Pembrolizumab (Keytruda) Plus Stereotactic Re-Irradiation versus SBRT Alone for Locoregionally Recurrent or Second Primary Head and Neck Carcinoma
Marcelo Bonomi, MD – A Controlled, Randomized Phase II Trial of Docetaxel plus Trastuzumab versus Ado-Trastuzumab Emtansine for Recurrent, Metastatic, or Treatment-Naive, Unresectable HER-2 Positive Salivary Gland Cancer
Marcelo Bonomi, MD – A Phase II Trial of the Efficacy and Safety of the Combination of Cemiplimab and Low-dose Paclitaxel and Carboplatin in Patients with Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck
Enver Ozer, MD – A Pilot Study Assessing Transoral Robotic Surgery (TORS) for Oral and Laryngopharyngeal Benign and Malignant Lesions Using the Da Vinci Robotic Surgical System
James Rocco, MD, PhD – Phase II Randomized Trial of Adjuvant Radiotherapy with or Without Cisplatin for p53 Mutated, Surgically Resected Squamous Cell Carcinoma of the Head and Neck (SCCHN)
James Rocco, MD, PhD – De-intensified Radiation Therapy with Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients with Early-stage, HPV-positive, Non-smoking Associated Oropharyngeal Cancer
Roman Skoracki, MD – Head and Neck Cancer Patient Symptoms and Oncologic Outcomes as a Function of Head and Neck Volume Changes
Emily Plowman, PhD – Dissemination and Implementation of DIGEST as an Evidence-based Measurement Tool in Cancer
Emily Plowman, PhD – Establishing Reference Values and Clinical Decision Points of Swallowing
Emily Plowman, PhD – Mechanisms, Predictors and Detection of Dysphagia in Cardiac Surgical Patients
Emily Plowman, PhD – Metformin: Effects on RAN Proteins, Breathing, Imaging, and Metabolomic Outcomes
Apoorva Ramaswamy, MD – Impact of Balloon Dilation on Swallowing Safety and Patient Reported Swallowing Function
Oliver Adunka, MD – Clinical Utility of Residual Hearing in the Cochlear Implant Ear
Oliver Adunka, MD – A Pivotal, Prospective, Multi-centre, Randomize Control, Blinded Study Evaluating the Efficacy of a Dexamethasone Eluting Slim Modiolar Electrode (CI632D) in the Reduction of Fribrosis as Compared to a Standard Slim Modiolar Electrode (CI632) in a Newly Implanted Adult Population with Bilateral, Post-linguistic, Moderate to Profound Sensorineural Hearing Loss
Oliver Adunka, MD – Expanded indications in the pediatric BoneBridge population
Ursula Findlen, PhD – A Natural History Study in Pediatric Participants With Hearing Loss Due to OTOF, GJB2, or GJB2/GJB6 Mutations
Shuman He, MD, PhD – Auditory Neural Function in Implanted Patients with Usher Syndrome
Kai Zhao, PhD – Olfactory Training for Patients With Olfactory Losses
Kai Zhao, PhD – Sinonasal Visualization and Quantification of the Effect of Oxymetazoline Nasal Spray