Active Research Funding FY2023
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Emily K. Plowman, Ph.D. 2/15/2023 - 1/30/2028 NCI R01CA271223
Dissemination and Implementation of DIGEST as an Evidence-based measurement tool in CancerEmily K. Plowman, Ph.D. 1/8/2022 – 7/30/2027 NIA R01AG077481
Establishing Reference Values and Clinical Decision Points for Quantitive Videofluoroscopic Measures of SwallowingEmily K. Plowman, Ph.D. 3/10/2022 – 12/31/2026 NINR R01NR01918
Mechanisms, Predictors and Detection of Dysphagia in Cardiac Surgical PatientsOliver Adunka, MD 08/01/2020 – 07/31/2025 NIH/NIDCD U01DC018920
Clinical Utility of Residual Hearing in the Cochlear Implant EarLauren Bakaletz, PhD 09/30/1999 – 03/31/2026 NIH/NIDCD R01DC003915
Determinants of H. influenzae Virulence in Otitis MediaTendy Chiang, MD 07/16/2021 – 06/30/2026 NIH/NHLBI R01HL157039
Tissue-Engineered Trachea Composites for Long-Segment Airway ReplacementThomas Cherpes, MD, DVM 07/01/2021 – 05/31/2023 NIH/NIDCD R01HD094634
Estrogen Reverses Progestin-mediated Loss of Genital Mucosal Barrier FunctionShuman He, MD, PhD 04/01/2023 – 03/31/2028 NIH/NIDCD R21DC019458
Auditory Neural Function in Implanted Patients with Usher SyndromeShuman He, MD, PhD 03/01/2020 – 02/28/2025 NIH/NIDCD R01DC018044
Encoding Temporal Fine Structure for Cochlear ImplantsShuman He, MD, PhD 09/12/2019 – 08/31/2024 NIH/NIDCD R01DC018701
Music Appreciation after Cochlear ImplantationShuman He, MD, PhD 04/01/2019 – 03/31/2024 NIH/NIDCD R01DC017846
Neural Encoding and Auditory Processing of Electrical Stimulation in Pediatric Cochlear Implant UsersDaniel Merfeld, PhD 09/01/2021 – 08/31/2026 NIH/NIA R01AG073113
Towards healthy aging: Quantifying vestibular contributors to age-related changes in balance and fall riskDaniel Merfeld, PhD 09/12/2020 – 03/23/2023 NIH/NIBIB R01EB029818
Moving MRI: Imaging a Moving Body with a Moving MRI MagnetYin Ren, MD, PhD 01/01/2023 – 12/31/2027 NIH/NIDCD K08DC020761
Engineering Protease Biomarkers to Guide Surgical Therapy for Vestibular Schwannoma and Neurofibromatosis Type 2James Rocco, MD, PhD 03/28/2019 – 02/28/2025 NCI/NCTN UG1CA233331
OSU as a Network Lead Academic Participating Site for the NCI NCTNJames Rocco, MD, PhD 07/18/2022 – 06/30/2027 NCI/NCTN R01CA265975
Racial Differences in Immunogenetic Tumorigenesis of Head and Neck Squamous Cell CarcinomaAndrew Wagner, MD 01/01/2023 – 12/31/2024 NIH/NIDCD K99ADC020759
Investigating Subthreshold Vestibular Stimulation as a Strategy for Rehabilitation in Individuals with Bilateral Vestibular HypofunctionRuili Xie, PhD 07/01/2022 – 06/30/2027 NIH/NIDCD R01DC016037
Auditory Nerve Synaptopathy and the Central Mechanisms Underlying Noise-induced Hearing LossRuili Xie, PhD 09/19/2017 – 06/30/2023 NIH/NIDCD R56DC019093
Cellular Mechanisms of Age Related Hearing LossKai Zhao, PhD 09/26/2022 – 07/31/2027 NIH/NIDCD R01DC020302
Novel Mechanisms and Therapeutic Approaches for Nasal Obstruction and Olfactory LossesKai Zhao, PhD 02/01/2023-01/31/2028 NIH/NIDCD R01DC020737
Short-term and Long-term Impact of COVID-19 on Multiple Sensory Systems -
Oliver Adunka, MD 08/15/2019 – 08/14/2023 DOD
Cochlear Synaptopathy Using ElectrocochleographyEugene Chio, MD 10/26/2022 – 10/26/2024 Inspire
The Predictor Study: Assessing Diagnostic Predictors of Airway Collapse in Patients with Obstructive Sleep ApneaEugene Chio, MD 06/22/2018 – 06/21/2024 Inspire
Adherence and Outcome of Upper Airway Stimulation (UAS) for Obstructive Sleep Apnea (OSA) International RegistryCasey Curtis, MD 02/08/2020 – 02/17/2024 AstraZeneca
A Multicentre, Randomised, Double-blind, Parallel-group, Placebo controlled, 24-week Phase 3 Study with an Open-label Extension to Evaluate the Efficacy and Safety of Benralizumab in Patients with Hypereosinophilic Syndrome (HES)Carrie Davenport, PhD 06/01/2022 – 05/31/2024 PCORI
Building Capacity for Engaging Families in Early Hearing Detection and Intervention ResearchVivian Kaul, MD 07/01/2022 – 06/30/2023 American Neurotology Society
Improving Patient Satisfaction and Quality of Life Outcomes for Cochlear Implant Patients through an Interactive Web and Mobile-Based Patient Education PlatformDaniel Merfeld, PhD 05/01/2023 – 04/30/2025 NAMRU-D
Vestibular Impacts on Human Behavior, Sleep, and PerformanceDaniel Merfeld, PhD 05/01/2020 – 04/30/2025 Office of Naval Research
Identifying Adverse Modes via Human Machine Cybernetic ModelingDaniel Merfeld, PhD 11/03/2022 – 01/17/2023 Soartech
Wing Instruction Spatial Disorientation Outcome Measure (WISDOM)Daniel Merfeld, PhD 04/15/2019 – 04/14/2024 DOD
Evaluating a Portable Virtual-Reality (VR) Balance Test as a Vestibular Assessment ScreenKyle VanKoevering, MD 10/13/2021 – 06/30/2023 NCI
Tissue Procurement Protocol for the Developmental Therapeutics Clinic
The Department of Otolaryngology – Head and Neck Surgery also continues to be a national leader in the exploration of ear, nose and throat, head and neck cancer, and human communication disorders through our active clinical trials.
Active Clinical Trials FY2023
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Casey Curtis, MD – Multicentre, Randomised, Double-blind, Parallel-group, Placebo-controlled, 24-week Phase 3 Study with an Open-label Extension to Evaluate the Efficacy and Safety of Benralizumab in Patients with Hypereosinophilic Syndrome (HES)
Casey Curtis, MD and Christopher Brooks, MD – A Randomized, Double-Blind, Placebo-controlled Study to Investigate the Efficacy and Safety of Depemokimab in Adults with Hypereosinophilic Syndrome -
Eugene Chio, MD – Adherence and Outcome of Upper Airway Stimulation (UAS) for Obstructive Sleep Apnea (OSA) International Registry
Eugene Chio, MD – Multicenter Study to Assess the Safety and Effectiveness of the Genio™ Dual-sided Hypoglossal Nerve Stimulation System for the Treatment of Obstructive Sleep Apnea in Adult Subjects
Eugene Chio, MD – The PREDICTOR Study: Assessing Diagnostic Predictors of Airway Collapse in Patients With Obstructive Sleep Apnea -
Amit Agrawal, MD – Randomized Phase II/III Trial of Sentinel Lymph Node Biopsy versus Elective Neck Dissection for Early-Stage Oral Cavity Cancer
Sujith Baliga, MD – Randomized Phase II/III Trial of Radiation with High-Dose Cisplatin (100 MG/M2) Every Three Weeks Versus Radiation with Low-Dose Weekly Cisplatin (40 MG/M2) for Patients with Locoregionally Advanced Squamous Cell Carcinoma of the Head and Neck (SCCHN)
Priyanka Bhateja, MD – A Phase II/III Randomized Study of Maintenance Nivolumab versus Observation in Patients with Locally Advanced, Intermediate Risk HPV Positive OPSCC
Priyanka Bhateja, MD – Phase I Trial with Expansion Cohort of DNA-PK Inhibition and IMRT in Cisplatin-Ineligible Patients with Stage 3-4 Local-Regionally Advanced Head and Neck Squamous Cell Carcinoma (HNSCC)
Priyanka Bhateja, MD – A Phase II, Open-Label, Multi-Center Study of PDS0101 (R-DOTAP [Versamune®] + HPVmix) and Pembrolizumab (KEYTRUDA®) Combination Immunotherapy in Subjects with Recurrent and/or Metastatic Head and Neck Cancer and High-Risk Human Papillomavirus-16 (HPV16) Infection
Priyanka Bhateja, MD – A Phase II Study of ALX148 in Combination with Pembrolizumab and Chemotherapy in Patients with Advanced Head and Neck Squamous Cell Carcinoma (Aspen-04)
Priyanka Bhateja, MD – A Phase II Study of ALX148 in Combination with Pembrolizumab in Patients with Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-03)
Dukagjin Blakaj, MD, PhD – Birinapant and Intensity Modulated Re-Irradiation Therapy (IMRRT) for Locoregionally Recurrent Head and Neck Squamous Cell Carcinoma (HNSCC)
Dukagjin Blakaj, MD, PhD – HNSALV Trial: Combining Immunotherapy with Salvage Surgery and IORT for Treatment of Persistent/Recurrent Head and Neck Cancers
Dukagjin Blakaj, MD, PhD – Randomized Phase II/III Trial of Surgery and Postoperative Radiation Delivered with Concurrent Cisplatin Versus Docetaxel Versus Docetaxel and Cetuximab for High-Risk Squamous Cell Cancer of The Head And Neck
Dukagjin Blakaj, MD, PhD – Keystroke: A Randomized Phase II Study of Pembrolizumab (Keytruda) Plus Stereotactic Re-Irradiation versus SBRT Alone for Locoregionally Recurrent or Second Primary Head and Neck Carcinoma
Marcelo Bonomi, MD – A Controlled, Randomized Phase II Trial of Docetaxel plus Trastuzumab versus Ado-Trastuzumab Emtansine for Recurrent, Metastatic, or Treatment-Naive, Unresectable HER-2 Positive Salivary Gland Cancer
Marcelo Bonomi, MD – A Phase II Trial of the Efficacy and Safety of the Combination of Cemiplimab and Low-dose Paclitaxel and Carboplatin in Patients with Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck
Enver Ozer, MD – A Pilot Study Assessing Transoral Robotic Surgery (TORS) for Oral and Laryngopharyngeal Benign and Malignant Lesions Using the Da Vinci Robotic Surgical System
James Rocco, MD, PhD – Phase II Randomized Trial of Adjuvant Radiotherapy with or Without Cisplatin for p53 Mutated, Surgically Resected Squamous Cell Carcinoma of the Head and Neck (SCCHN)
James Rocco, MD, PhD – De-intensified Radiation Therapy with Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients with Early-stage, HPV-positive, Non-smoking Associated Oropharyngeal Cancer
Roman Skoracki, MD – Head and Neck Cancer Patient Symptoms and Oncologic Outcomes as a Function of Head and Neck Volume Changes -
Brad deSilva, MD – Voice Outcomes Following Transcutaneous Steroid Injection for Vocal Fold Nodules Combined With Voice Therapy Compared to Voice Therapy Alone
Emily Plowman, PhD – Dissemination and Implementation of DIGEST as an Evidence-based Measurement Tool in Cancer
Emily Plowman, PhD – Establishing Reference Values and Clinical Decision Points of Swallowing
Emily Plowman, PhD – Mechanisms, Predictors and Detection of Dysphagia in Cardiac Surgical Patients
Emily Plowman, PhD – Metformin: Effects on RAN Proteins, Breathing, Imaging, and Metabolomic Outcomes
Apoorva Ramaswamy, MD – Impact of Balloon Dilation on Swallowing Safety and Patient Reported Swallowing Function -
Oliver Adunka, MD – Cochlear Implantation During Vestibular Schwannoma Removal or During Labyrinthectomy Surgery for Treatment of Meniere’s Disease
Oliver Adunka, MD – Clinical Utility of Residual Hearing in the Cochlear Implant Ear
Oliver Adunka, MD – A Pivotal, Prospective, Multi-centre, Randomize Control, Blinded Study Evaluating the Efficacy of a Dexamethasone Eluting Slim Modiolar Electrode (CI632D) in the Reduction of Fribrosis as Compared to a Standard Slim Modiolar Electrode (CI632) in a Newly Implanted Adult Population with Bilateral, Post-linguistic, Moderate to Profound Sensorineural Hearing Loss
Oliver Adunka, MD – Expanded indications in the pediatric BoneBridge population
Ursula Findlen, PhD – A Natural History Study in Pediatric Participants With Hearing Loss Due to OTOF, GJB2, or GJB2/GJB6 Mutations
Shuman He, MD, PhD – Auditory Neural Function in Implanted Patients with Usher Syndrome -
Kai Zhao, PhD – 3D Printing to Improve Nasal Irrigation Outcomes
Kai Zhao, PhD – Olfactory Training for Patients With Olfactory Losses
Kai Zhao, PhD – Sinonasal Visualization and Quantification of the Effect of Oxymetazoline Nasal Spray