Understanding the causes of nasal obstruction

• Grants and Funding

  Title: A confectionary-based screening tool for assessing chemosensory loss in COVID-19 patients
  Agency: NIH-NIDCD, 3R01 DC016112-04S1
  PI: Susan Travers
  Co-Investigator: Kai Zhao, PhD
  12/21/2020 – 12/20/2021

  Title: Noninvasive Nasal Aid to Improve Nasal Obstruction Symptoms
  Agency: Ohio State Dept. of Education, Accelerator Awards
  PI: Kai Zhao, PhD
  1/1/2020 - 6/31/2021
  
  Title: Optimizing surgical outcomes to olfactory losses through endoscopic sinus surgery simulator
  Agency: NIH-NIDCD, R21 DC017530
  PI: Kai Zhao, PhD
  3/1/2019 - 3/1/2021
  
  Title: Sinonasal Visualization and Quantification of the Effect of Oxymetazoline Nasal Spray
  Agency: Bayer, Inc.
  PI: Kai Zhao, PhD

• Publications

  1. Wu Z., Zhao K. (2021) Impact of pulsation rate and viscosity on taste perception – application of a porous medium model for human tongue surface, Computers in Biology and Medicine (In press).
  
  2. Liu L, Sayali Dharmadhikari S, Shontz KM, Tan ZH, Spector BM, Manning A, Zhao K., Reynolds SD, Breuer CK, Chiang T. (2021) Regeneration of partially decellularized tracheal scaffolds in a mouse model of orthotopic tracheal replacement, Journal of Tissue Engineering (in press).
  
  3. Wu Z. and Zhao K. (2020) Taste of time: a porous-medium model for human tongue surface with implications for early taste perception, Plos Computational Biology, 16(6): e1007888. doi: 10.1371/journal.pcbi.1007888. PMC7271999
  
  4. Mateusz Choiński, Natalia Gawron, Agnieszka Pluta, Marta Sobańska, Anna R. Egbert, Przemysław Bieńkowski, Halina Sienkiewicz-Jarosz, Anna Ścińska-Bieńkowska, Bogna Szymańska, Andrzej Horban, Ewa Firląg-Burkacka, Tomasz Wolak, Mateusz Rusiniak, Robert Bornstein, Kai Zhao, Emilia Łojek (2020) On the relationship between olfactory sensitivity and personality in HIV-seropositive and healthy men, Current Psychology, 39:1063–1071, doi.org/10.1007/s12144-018-9822-x
  
  5. Malik J., Dholakia S., Spector BM., Yang A., Kim D., Borchard NA., Thamboo A.,  Zhao K., Nayak JV. (2020) Inferior meatus augmentation procedure (IMAP) normalizes nasal airflow patterns in empty nose syndrome patients via computational fluid dynamics (CFD) modeling, International Forum of Allergy Rhinol, 2020 Nov 29. doi:10.1002/alr.22720, PMC1636956
  
  6. Kim K., Otto B.A., Farag A.A., Zhao K. (2020) Topical irrigation against gravity may lead to better sinus penetration, International Forum of Allergy Rhinol, Feb;11(2):198-200. doi: 10.1002/alr.22711 PMC1636084 (in press).
  
  7. Wu Z., Krebs J.P., Spector B.M., Otto B.A., Zhao K., Farag A.A (2020) Regional peak mucosal cooling predicts radiofrequency treatment outcomes of nasal valve obstruction, Laryngoscope, Nov 3. doi: 10.1002/lary.29223.
  
  8. Turfe Z., Zhao K., Palmer J. and Craig J. (2020) Computational fluid dynamic modeling of maxillary sinus irrigation after maxillary antrostomy and modified endoscopic medial maxillectomy, Journal of Laryngology and Otology, doi.org/10.1017/S0022215121000013 (in press).
  
  9. Li C., Dong H., and Zhao K. (2020) Dual functions of insect wings in an odor-guided aeronautic navigation, Journal of Fluids Engineering 142(3), 030902. doi.10.1115/1.4045946
  
  10. Zhao K., Kim K., Craig JR., Palmer JN. (2020) Using 3D printed sinonasal models to visualize and optimize personalized sinonasal sinus irrigation strategies, Rhinology (in press).
  
  11. Malik J, Thamboo A, et al. The cotton test redistributes nasal airflow in patients with empty nose syndrome. Int Forum All Rhinol. 2020 Jan 17. doi: 10.102/alr.22489
  
  12. Wu Z., Craig JR., Maza G., Li C., Otto BA., Farag AA., Carrau RL., Zhao K. (2020) Peak sinus pressures during sneezing in healthy controls and post-skull base surgery patients, Laryngoscope,  doi:10.1002/lary.28400.

• Research

  Nasal Obstruction: This ongoing study aims to develop and validate an objective diagnostic tool by combining novel computational models with sensory measurements, which would enable patients and clinicians to make informed, personalized treatment/surgery strategy. This project has also led to invention of novel non-surgical treatment option. Specific areas:

  • Turbinate hypotrophy
  • Septal deviation
  • Septal perforation
  • Empty Nose syndrome
  • Skull base patients
  • Obstruction related smell loss

  Nasal Drug Delivery: This ongoing study uses computational models and 3D printing to optimize surgical impact for nasal drug delivery. The project also explores novel drug delivery methodology.

  Endoscopic Sinus Surgery Simulator: This ongoing study aims to develop and validate a virtual endoscopic sinus surgery simulator to simulate, predict, and optimize surgical approaches that may improve clinical practice and offer personalized medicine in the future.
  
  Olfaction Function and Training: Investigating the impact of nasal aerodynamics on olfactory function; the use of olfactory training and novel modulation of nasal airflows to improve olfactory function in both healthy controls and patients with reported smell losses.

   

• Contact Information

  If you are interested in participating in any of our studies or would like more information about our lab, please call 614-366-1794 or email Bhakthi.Deshpande@osumc.edu or Kai.Zhao@osumc.edu.