Innovations in cardiac surgery at Ohio State
The Department of Surgery's research efforts are focused on key areas of interest that promise to yield significant results in the understanding of disease and the improvement of clinical care.
Research Interests
Research plays an essential role in the advancement of cardiac surgery and in the never ending quest to improve the outcomes of cardiac surgery patients. Through research, we develop new procedures to treat ill patients and help patients live better, longer lives. The research activities of our division explore basic science by understanding and analyzing muscle biology and cell membrane repair. Our team also excels in translational research with studies of resuscitation of lungs before transplant and also in clinical research, where we evaluate new and smaller ventricular assist devices and valves. We also have a strong clinical outcomes research group that evaluates the impact of delivery of care on cardiac surgery outcomes.
The division has also has a strong interest in training the next generation of cardiac surgeons. As such, we welcome medical students and residents to participate in our clinical and research activities.
Outcomes Research
“The Outcomes Center in the Division of Cardiac Surgery is designed to better understand and appreciate various factors that go into minimizing complications and improving patient outcomes. It is centered around gaining a deeper appreciation of the multiple factors that go into having successful surgical outcomes, including collaboration between research staff, nurses, coordinators, statisticians, epidemiologists, basic scientists and clinicians to foster a center of inquisitiveness and an ever constant push for improvements in the way we deliver care. As the director of the Outcomes Center, it is my hope that this collaboration fosters an environment conducive to researching new ideas and allows us the opportunity to teach each other to become better in our respective fields.”
Clinical Trials
For more information on cardiac surgery clinical trials, please contact the Heart and Vascular Research Organization (HVRO) at Cardiovascular.Research@osumc.edu or speak with your doctor at your next appointment.
We currently have clinical trials open in the following areas:
ReFresh II - CytoSorb® Reduction of Free Hemoglobin/Acute Kidney Injury (AKI) During Cardiac Surgery
GUARD - A Multicenter, Prospective, Parallel-Group, Double-Blind, Randomized, Placebo-Controlled, Phase 2 Study of ANG-3777 (formerly BB3) to Assess the Safety and Efficacy of ANG-3777 in Patients Developing Acute Kidney Injury After Cardiac Surgery
EXACT - A Phase 1/2 Trial of Direct Administration of AdVEGF-All6A+, a Replication Deficient Adenovirus Vector Expressing a cDNA/Genomic Hybrid of Human Vascular Endothelial Growth Factor, to the Ischemic Myocardium of Subjects with Angina Pectoris Secondary to Coronary Artery Disease that is Refractory to Drug Therapy and Unsuitable for Revascularization (XC001-1001)
EXPAND CAP - Continued Access Protocol to collect additional evidence to evaluate the Safety and Effectiveness of The Portable Organ Care System (OCS™) Heart For Preserving and Assessing Expanded Criteria Donor Hearts for Transplantation
SHORE - Surveillance Heartcare Outcomes Registry. Prospective, multi-center, observational, registry of patients receiving HeartCare for surveillance.
Novel Extension HUD - XVIVO Perfusion System (XPS™) with STEEN Solution™ Perfusate Humanitarian Use Device
NOVA - A Phase 2, Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Evaluate the Efficacy and Safety of Botulinum Toxin Type A(AGN-151607) Injections into the Epicardial Fat Pads to Prevent Post-Operative Atrial Fibrillation in Patients Undergoing Open-Chest Cardiac Surgery
APOLLO - Transcatheter Mitral Valve Replacement with the Medtronic Intrepid™ TMVR System in patients with severe symptomatic mitral regurgitation
CLASP IID/IIF - A prospective, multicenter, randomized, controlled pivotal trial to evaluate the safety and effectiveness of transcatheter mitral valve repair with the Edwards PASCAL Transcatheter Valve Repair System compared to Abbott MitraClip in patients with mitral regurgitation (2018-07)
CLASP II TR - Edwards PASCAL TrAnScatheter Valve RePair System Pivotal Clinical Trial (CLASP II TR): A prospective, multicenter, randomized, controlled pivotal trial to evaluate the safety and effectiveness of transcatheter tricuspid valve repair with the Edwards PASCAL Transcatheter Valve Repair System and optimal medical therapy (OMT) compared to OMT alone in patients with tricuspid regurgitation
Lyten - Comparison of the Balloon-Expandable Edwards Valve and Self-Expandable CoreValve System for the Treatment of Small, Severely Dysfunctional Surgical Aortic Bioprostheses: A Pilot Prospective Randomized Trial.
HVAD DT PAS - Destination Therapy Post Approval Study (DT PAS) Product Surveillance Registry (PSR) Platform Addendum
INTERMACS – Interagency Registry for Mechanically Assisted Circulatory Support
MOMENTUM PAS - Momentum 3 Pivotal Cohort Extended Follow-up Post-Approval Study