The research we perform at the Ohio State Comprehensive Transplant Center covers basic, translational and clinical, with the goal of developing the next generation of surgical innovation.
What we learn at the bench, we apply to the bedside.
Active clinical trials
Kidney Transplant
APOLLO: APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Long-term Kidney Transplantation Outcomes Network
- Principal Investigator:
Todd Pesavento, MD
Email: Todd.Pesavento@osumc.edu - Summary:
The APOLLO study aims to improve outcomes following kidney transplantation and enhance the safety of living kidney donation by investigating variations in the apolipoprotein L1 gene (APOL1). Genes determine inherited traits such as eye color and blood type. Certain variations in the APOL1 gene have been linked to an increased risk of kidney disease. Individuals of African American, Afro-Caribbean, Hispanic Black, and African descent are more likely to possess these APOL1 variants. The APOLLO study will analyze DNA from both kidney donors and recipients to assess the impact of APOL1 on transplant-related outcomes. - Study Details
APPELHUS: Efficacy and Safety of Iptacopan (LNP023) in Adult Patients With Atypical Hemolytic Uremic Syndrome Naive to Complement Inhibitor Therapy
- Principal Investigator:
Uday Nori, MBBS
Email: uday.nori@osumc.edu - Summary:
This multicenter, single-arm, open-label study will evaluate the efficacy and safety of iptacopan (LNP023) 200 mg twice daily in about 50 adult aHUS patients who have not previously received complement inhibitor therapy, measuring outcomes such as hematological and kidney function, dialysis needs, CKD stage changes, and patient-reported quality of life and fatigue. - Study Details
Computerized Image Analysis of Pathology Images to Predict Kidney Failure Timing: Developing an Imaging-Based KDPI Alternative
- Principal Investigator:
Ajay Thakur, MBBS
Email: ajay.thakur@osumc.edu - Summary:
The model will leverage machine learning techniques, utilizing whole slide images (WSI) of H&E-stained kidney biopsies. Key histopathologic features such as fibrosis, tubular atrophy, vascular damage, and glomerular alterations will be identified and quantified. These features will then be used to predict graft failure timing. The development of a robust, image-based model will provide clinicians with a tool that can make accurate predictions regarding the likelihood of kidney graft failure, offering a direct and data-driven method to evaluate donor organs.
Does timing of Rabbit Anti-Thymocyte Globulin (rATG) induction post-operatively determine kidney transplant outcomes?
- Principal Investigator:
Navdeep Singh, MBBS
Email: navdeep.singh@osumc.edu - Summary:
This retrospective study examines the impact of timing for Rabbit Anti-Thymocyte Globulin (rATG) administration after kidney transplantation at OSUWMC from January 1, 2017, to January 31, 2021. Using data from the EPIC database, the study will assess whether the timing of post-operative ATG affects transplant outcomes, as there is currently no established guideline for optimal administration post-reperfusion.
(TANGO) Incidence of Glomerular Disease Post-Kidney Transplant
- Principal Investigator:
Ajay Thakur, MBBS
Email: ajay.thakur@osumc.edu - Summary:
This retrospective cohort study measures how often glomerular disease occurs after kidney transplant and examines allograft survival.
Investigating the Phenotype, Effector Function, and Clinical Correlations of Peripheral Blood Lymphocytes in Kidney Transplant Recipients
- Principal Investigator:
Ginny Bumgardner, MD, PhD
Email: ginny.bumgardner@osumc.edu - Summary:
This study evaluates whether specific subsets of CD8+ T cells in human kidney transplant recipients can suppress donor-specific antibody production and promote viral clearance. Transplant recipients will donate blood before and after surgery, with immune cell quantities analyzed in relation to clinical outcomes such as antibody formation and viral infections.
Renal Function Recovery in Liver Transplant Recipients
- Principal Investigator:
Austin Schenk, MD, PhD
Email: austin.schenk@osumc.edu - Summary:
Predicting kidney recovery after liver transplantation is difficult, especially for patients undergoing simultaneous liver–kidney transplants (SLK). Nuclear scintigraphy can directly measure kidney-specific function and differentiate between native and transplanted kidneys post-SLK. This study aims to use this technique to assess native kidney recovery and identify reliable clinical predictors, helping selection committees make informed decisions about transplant eligibility and allocation.
Shamrock: A Study to Evaluate the Safety and Tolerability of Efgartigimod PH20 SC Given by Prefilled Syringe in Kidney Transplant Recipients With Antibody-Mediated Rejection (AMR)
- Principal Investigator:
Todd Pesavento, MD
Email: Todd.Pesavento@osumc.edu - Summary:
This study evaluates the safety, tolerability, and effectiveness of subcutaneous efgartigimod PH20 SC in kidney transplant recipients with antibody-mediated rejection, with treatment over 48 weeks and follow-up for up to 24 weeks, totaling up to 78 weeks of participation. - Study Details
SPARX: Sparsentan in Posttransplant Immunoglobulin A Nephropathy or Focal Segmental Glomerulosclerosis
- Principal Investigator:
Todd Pesavento, MD
Email: Todd.Pesavento@osumc.edu - Summary:
This 46-week, Phase 4 study evaluates the safety and efficacy of sparsentan in kidney transplant patients with IgAN or FSGS and proteinuria, enrolling those receiving stable immunosuppressive therapy and standard of care. - Study Details
TRANSCEND: A Double-Blind, Placebo-Controlled, Multicenter, Randomized Phase 3 Trial Evaluating the Efficacy and Safety of Felzartamab in Kidney Transplant Recipients with Late Antibody-Mediated Rejection (AMR)
- Principal Investigator:
Todd Pesavento, MD
Email: Todd.Pesavento@osumc.edu - Summary:
This study examines the effects of felzartamab in kidney transplant patients experiencing antibody-mediated rejection (AMR), a condition where the immune system attacks the transplanted organ and may cause organ failure. - Study Details
TRANSPIRE: A Study to Learn About the Effects of Felzartamab Infusions on Adults With Kidney Transplants Who Have Late Isolated Microvascular Inflammation
- Principal Investigator:
Todd Pesavento, MD
Email: Todd.Pesavento@osumc.edu - Summary:
This study examines the effects of felzartamab in kidney transplant recipients who develop microvascular inflammation, a condition that may indicate rejection and lead to kidney problems. The primary objective is to determine how many participants show no signs of active kidney inflammation after 24 weeks of treatment, while also monitoring kidney function, immune responses, and safety through various assessments. - Study Details
VARVARA: ARGX-117 in Deceased Donor Kidney Transplant Recipients at Risk for Delayed Graft Function
- Principal Investigator:
Navdeep Singh, MBBS
Email: navdeep.singh@osumc.edu - Summary:
This study evaluates the safety, efficacy, and tolerability of ARGX-117 versus placebo in deceased donor kidney transplant recipients at risk for delayed graft function, with up to 64 weeks to 5 years of follow-up. - Study Details
Liver Transplant
Liver Graft Dysfunction Protocol
- Principal Investigator:
Sylvester Black, MD, PhD
Email: sylvester.black@osumc.edu - Summary:
In the US, over 36,000 people die each year from cirrhosis and liver disease, while many on transplant waitlists die due to organ shortages. To address this, centers are considering marginal organs, though current tests can't reliably predict their success. This study aims to improve prediction and reduce inflammation in these organs, ultimately seeking better outcomes for liver transplant patients.
Normothermic Machine Perfusion and Static Cold Storage in Liver transplantation: a single center experience
- Principal Investigator:
Kenneth Washburn, MD
Email: ken.washburn@osumc.edu - Summary:
Comparison of Normothermic machine perfusion compared to static cold storage in liver transplantation.
Palliative Care Utilization for Older Adults with End Stage Liver Disease
- Principal Investigator:
Brittany Waterman, MD
Email: brittany.waterman@osumc.edu - Summary:
This study will evaluate patterns of palliative care (PC) utilization among older adults with end-stage liver disease (ESLD) referred for liver transplant evaluation, analyzing factors associated with PC referral, timing in relation to hospice and death, and relevant outcomes. Findings will guide the development of improved care models for this high-need population by identifying current barriers and informing future prospective research on patient and provider experiences.
Lung Transplant
VIP BOLT: Veno-Arterial ECMO Versus Off-Pump Bilateral Orthotopic Lung Transplantation
- Principal Investigator:
Bryan Whitson, MD, PhD
Email: Bryan.Whitson@osumc.edu - Summary:
The VIP BOLT trial is a multicenter prospective randomized trial that aims to compare the effectiveness of veno-arterial ECMO (VA ECMO) and off pump bilateral orthotopic lung transplantation (BOLT) in terms of primary graft dysfunction (PGD) and other outcomes. The trial is designed to provide insights into which method may lead to better outcomes for patients undergoing bilateral lung transplantation.
Multi Organ Transplants
Effect of Prophylactic Treatment for Osteoporosis on Progression of Bone Mineral Density and Fractures in Lung, Heart and Liver Transplant Recipients
- Principal investigator:
Priya Singh, MBBS
Email: priyamvada.singh@osumc.edu - Summary:
Between 2005 and 2020, all lung transplant recipients at Ohio State University Medical Center were automatically placed on prophylactic osteoporosis treatment, while heart and liver transplant recipients served as controls. This study will retrospectively analyze changes in bone mineral density, fracture rates, and other bone metabolism markers from DEXA scans and clinical data to assess the impact of prophylactic therapy and identify associated adverse effects.
Retrospective Study of Patients with Postoperative Pseudoaneurysms Following Simultaneous Pancreas-Kidney Transplantation
- Principal Investigator:
Navdeep Singh, MBBS
Email: navdeep.singh@osumc.edu - Summary:
This study retrospectively examines how often pseudoaneurysms occur after pancreas-kidney transplants in patients with end-stage renal disease caused by type 1 diabetes at Ohio State University Wexner Medical Center, covering the period from January 1, 2012 to July 31, 2023. Data on deceased donors will also be collected from UNOS.
(TTCP) Total Transplant Care Protocol
- Principal Investigator:
Kenneth Washburn, MD
Email: ken.washburn@osumc.edu - Summary:
The Comprehensive Transplant Center Human Tissue Biorepository is launching the Total Transplant Care Protocol (TTCP) to securely collect and store patient specimens and clinical data for research at Ohio State University. The initiative gathers samples like blood, tissue, and fluids alongside health records from CTC patients to support studies on organ failure and transplantation. All materials are managed under strict protocols to advance understanding and improve transplant outcomes.
Islet Transplant
TPIAT: Observational Study of Patients Undergoing Total Pancreatectomy and Islet Autotransplantation
- Principal Investigator:
Amer Rajab, MD, PhD
Email: amer.rajab@osumc.edu - Summary:
Chronic pancreatitis is a painful, progressive disease that often leads to loss of pancreatic function and may require total pancreatectomy with autologous islet transplantation to reduce the risk of diabetes and improve quality of life. Evaluating the effectiveness and timing of TPIAT is crucial to identify which patients benefit most and to enhance future treatment approaches.
Infectious Disease
ESGREV: Outcomes of Respiratory Syncytial Virus Infections – a multi-center international consortium, on behalf of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Respiratory Viruses
- Principal Investigator:
Nicholas Marschalk, DO
Email: nicholas.marschalk@osumc.edu - Summary:
This multi-center study will compare outcomes such as 30-day RSV-related mortality, progression to lower respiratory tract infection, and hospital or ICU admission among different patient groups diagnosed with RSV. It also aims to identify risk factors for these outcomes and describe management strategies, including antiviral therapy and vaccination, to clarify which populations may benefit most from RSV vaccines.
Active Research Grants
Active and pending grants
- Ginny Bumgardner MD, PhD – NIH T32 grant - Advancing Research Training in Immunology for Surgery Trainees (ARTIST), National Institutes of Health, (NIH, NIAID), 8/1/2014–7/31/2029, $2,326,965
- Ginny Bumgardner MD, PhD – NIH R01 grant - Investigating a Novel Cellular Therapy to Prevent and Treat Acute Antibody Mediated Kidney Transplant Rejection, (NIH, NIAID) 7/1/2019–6/30/2024, $2,686,090
- Ginny Bumgardner MD, PhD – NIH T32 grant - Medical Scientist Training Program, The Ohio State University, (NIH, NIGMS), 7/1/2021–6/30/2026, $4,189,808
- Ginny Bumgardner MD, PhD – NIH T32 grant - Predoctoral Research Training in Clinical and Translational Science, The Ohio State University, (NIH, NCATS) 10/2023–10/2028, $1,500,000
- Ginny Bumgardner MD, PhD – NIH R38 grant - OSU Stimulating Access to Research in Residency, (NIH, NIAID) 7/1/2024–6/30/2029, $2,063,065
- Ginny Bumgardner MD, PhD – Doris Duke Charitable Foundation grant, Physician Scientist Retention in Research, 10/15/2021–10/14/2023, $550,000
- Ginny Bumgardner MD, PhD – NIH T35 grant - Short-term Research in Immunology and Virology Experience (STRIVE), National Institutes of Health, (NIH, NIAID), 5/1/2025–4/30/2030, $525,850
- Bryan Whitson, MD, PhD – NIH NHLBI R01 grant - Investigating an Artificial Blood Substitute HBOC to Support Extended Duration Ex Vivo Lung Perfusion, 7/15/2025–4/30/2029, $784,227
- Austin Schenk, MD, PhD – R01, Impact of ableism and state laws designated to mitigate ableism on organ transplant equity for kidney transplant candidates with intellectual or development disabilities, 8/1/2024–6/30/2029, $2,535,815
