Focusing on cardiovascular regeneration through the use of stem-cell therapy
The damaged heart following a myocardial infarction (MI) leaves a scar that weakens the heart muscle which ultimately leads to heart failure. As promising as stem-cell therapy is, there is a significant amount of optimization needed, due to the poor survival of stem cells in the ischemic heart, in order to effectively treat patients with MI. Our lab is at the forefront as we focus on reprogramming human induced pluripotent stem cells (hiPSCs) into cardiac and endothelial lineage for repairing the failing heart tissue as well as discovering the mechanisms and conditions necessary to enhance and ensure the survival and engraftment of stem cells post transplantation into the ischemic myocardium.
This therapeutic approach is meant to recover functionality lost in the damaged heart. With the goal of seeding the cells on our bioengineered nanofiber cardiac patch capable of promoting angiogenesis in the ischemic heart. Remarkable progress has been made as transplantation has proven successful in small and large animal models which will ultimately aid clinical translation in the future. Our lab also focuses on developing nanoparticles as means of acellular therapy to target the myocardium following an MI.
Dr. Khan’s lab is located on the 5th floor of the Pelotonia Research Center. We are a growing team of experts equipped with cutting edge technology. Visit u.osu.edu/KhanLab to learn more, stay up to date on our progress, and connect with the lab for observational and training opportunities
Research interests Include:
- Cardiovascular Disease
- Myocardial Infarction
- Reprogramming of Induced Pluripotent Stem Cells (iPSCs)
- Exosomes
- Nanoparticles
- Angiogenesis
- Hypoxia
- Bioengineering scaffolds and cardiac repair
- EPR Oximetry and Oxygenomics
Our Researchers
- Mahmood Khan, PhD, Professor, Director: Division of Basic and Translational Sciences
- Divya Sridharan, PhD, Research Scientist
- Syed Alvi, PhD, Post Doc
- Pankaj Dholaniya, PhD, Post Doc
- Helena Islam, PhD, MBBS, Post Doc
- Muhamad Mergaye, Lab Manager
- Khaled Asir, Foreign Medical Graduate
- Salvia Zafar, Medical Student
- Uzair Ahmed, Student
- Syed Ashraf, Student
- Anant Batchu, Student
- Ayza Choudhry, Student
- Collete Janik, Student
- Lubna Malimar, Student
- Nikolina Racic, Student
- Mehrukh Sofi, Student
- Navisha Soni, Student