Department of Radiology’s advancements in imaging science
Imaging science is dedicated to exploring and advancing magnetic resonance imaging (MRI), computed tomography (CT), ultrasound, single photon emission computed tomography (SPECT), positron emission tomography (PET) and X-ray. The main interests of the group are DCE-MRI of tumors, cardiovascular contrast agents, magnetic resonance angiography (MRA), angiogenesis and molecular imaging. In addition to research within the aforementioned areas, the imaging science team conducts web-based conferencing with a number of collaborators, including the Ohio Supercomputer Center (OARnet), NIH/Clinical Center and biomedical informatics.Wright Center of Innovation in Biomedical Imaging
The Wright Center received a $9.1 million Third Frontier Grant from Ohio Governor Bob Taft and $8 million from BRTT (the Biomedical Research and Technology Transfer award) to create the Wright Center of Innovation in Biomedical Imaging. The project is also known as the Biomedical Structural, Functional and Molecular Imaging Enterprise.
In addition to The Ohio State University, project collaborators include Case Western Reserve University, Philips Medical Systems of Highland Heights and the Ohio Supercomputer Center.
Our Location
WCI-BMI: Concourse Building
Martha Morehouse Medical Plaza
2050 Kenny Road
Columbus, OH 43221
Contact:
OSURADADMIN@osumc.edu
- The creation of an ultra-high-field 7 Tesla MRI scanner, which will reduce the need for exploratory surgery and permit doctors to closely monitor the effects of medications. It will enable functional imaging research in cancer, neuroscience and cardiovascular care at Ohio State
- Development of a new and more powerful PET scanner to help physicians better understand disease processes and treatment
- Exploration into mobile imaging facilities and remote access systems that would facilitate advanced diagnostic and imaging capabilities in the field during quickly changing and demanding biohazard events
- Organization of a powerful, extensive imaging and bioinformatics infrastructure that will integrate the state's scientific community into a virtual think tank for research and development
- Provide startup funding in the amount of $1 million for support of innovative and promising imaging projects
- One 3T clinical MRI (Achieva, Philips, Cleveland, Ohio)
- One 7T human, preclinical MRI (Achieva, Philips, Cleveland, Ohio)
- 64-slice Mobile PET/CT system (Philips, Cleveland, Ohio)
Animal Imaging
The 4.7T/40cm MRI facility was created as part of the Ohio Cellular and Molecular Imaging Consortium (OCMIC) with the goal to advance state-of-the-art technology for animal imaging at the molecular, cellular and system level, to serve as a resource for medical research, biotechnology advances and pharmaceutical development, and for probing in-vivo gene function, disease processes and therapeutic applications including drug delivery and trials. The goal of the consortium is to facilitate inter-institutional collaboration between academic institutions in Ohio and technology transfer to Industry.
Our Location
Animal MRI Facility (4.7T)
N113 Wiseman Hall
400 W. 12th Ave.
Columbus, OH 43210
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Program Director:
Petra Schmalbrock, PhD
- Medium sized animals (less than 20 cm) using the 260 mm inner diameter gradient coil (max. 100 mT/m, 280 microseconds rise time, diameter of spherical volume: 18.0 cm, shielded, water cooled) with a 200 mm inner diameter proton volume RF coil
- Small animals (less than seven cm) using the 120 mm inner diameter gradient coil (max. 400 mT/m, 170 microseconds rise time, diameter of spherical volume: 8.0 cm, shielded, water cooled) with a 72 mm inner diameter proton volume RF coil
The system is equipped with the Bruker BioTrig monitoring unit for the display of physiological monitoring and for synchronization of MR acquisitions by using ECG or respiration triggering signals. The system is equipped with respiratory sensory pads, a temperature probe, a set of ECG electrodes and a laptop PC.
Cost for instrument access
Cost of operation and maintenance of the facility will be shared by the users. Based on initial estimates for the annual operating budget (personnel costs, instrument maintenance and supplies) and comparison with rates at comparable facilities the following rates have been established. Budget, costs and rates will be reviewed annually.
- $320/hour for commercial and out-of-state users
- $200/hour reduced rate for in-state academic users
- $1200/day reduced daily rate for in-state academic users
Additional charges (these charges will be assessed if not provided by user).
- Animal handling including gas anesthesia (equipment loan from ULAR) and supplies, e.g. isoflurane (at cost)
- Data analysis
- MRI contrast agent at cost
- Usage of computer workstations
Imaging Core Laboratory
The Imaging Core Laboratory (ICL) through the Wright Center of Innovation at The Ohio State University performs visual reads, quantification, lesion tracking, perfusion and metabolic mapping, pharmacokinetic analysis, quantification of lesion heterogeneity, 3D segmentation and rendering in addition to conventional methodologies such as RECIST/WHO, volume tracking and morphologic characterization.
Our Location
Imaging Core Lab (ICL)
Wright Center of Innovation in Biomedical Imaging
395 W. 12th Ave., Room 414
Columbus, OH 43210
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- PET and CT
- CT
- MRI
- X-ray
- Mammography
- Nuclear medicine studies
- Preclinical validation for translational studies including uCT, uPET/CT, uSPECT/CT
In final stages of development for core lab services:
- SPECT and CT
- MRS
- Neurofunctional imaging
Additional generic imaging services are offered:
- Imaging trial design and GCP compliance
- Blinded read of diagnostic and therapy assessment studies with electronic tracking
- Trial progress assessment and reporting
- Site qualification
- Site training and QA oversight
- Compliance review
- External trial review
- Site visit services – virtual and on-site
- Multi-language support for trial information and communications
- Trial enrollment and performance tracking with automated reporting
- DICOM consultation services
- Database transfer
- caBig connectivity and consulting services
Microimaging Lab
The Biomedical Research Tower (BRT) is a 10-story, 403,000-square-foot facility housing more than 180,000 square feet of lab space. The BRT is the largest research facility on The Ohio State University campus, nearly doubling the amount of biomedical research space on campus.
The Microimaging Laboratory is housed within the lower level of the BRT. It serves as part of the advanced structural, functional and molecular animal imaging infrastructure. The facility is part of the Wright Center of Innovation in Biomedical Imaging resources/services.
Our Location
Microimaging Lab
Wright Center of Innovation in Biomedical Imaging
460 W. 12th Ave., 0080 BRT, Box #41
Columbus, OH 43210
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Molecular Imaging Agent Laboratory
The Molecular Imaging Agent Laboratory is housed within the Biomedical Research Tower on the seventh floor. The facility is part of the Wright Center of Innovation in Biomedical Imaging Resources and Services.
The laboratory, led by Dr. Michael Tweedle, pursues problems in cancer diagnosis and therapy using biochemical in-vivo imaging. The goal is hyper-effective cancer therapy through biochemically personalized treatment.
Our Location
Microimaging Lab
Wright Center of Innovation in Biomedical Imaging
460 W. 12th Ave., 0080 BRT, Box #41
Columbus, OH 43210
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Program Director:
Michael F. Tweedle, PhD
Wright Center of Innovation Research Teams
Imaging Science Faculty
Associate Professor, Ohio Molecular Imaging Scholar
Director, Laboratory for Translational Research in Imaging Pharmaceuticals
Michael Tweedle, PhD
Professor, Stefanie Spielman Chair in Cancer Imaging
Xiangyu Yang, PhD
Assistant Professor, Medical Physicist
Adjunct Assistant Professor
Guang Jia, PhD
Adjunct Assistant Professor
Robert R. McKenney, PhD, FAAMA
Adjunct Assistant Professor
Juergen Reichenbach, PhD
Adjunct Professor
Steffen Sammet, MD, PhD
Adjunct Assistant Professor
Hendrik von Tengg-Kobligk, MD
Adjunct Instructor