Hansen_02-2019Brian Hansen

Area of Study: Cardiac Electrophysiology
Hometown:
Dublin, OH

ACADEMICS

Research interests
I am interested in mechanisms of cardiac arrhythmias and how mechanistic understanding can guide novel imaging and treatment engineering.

Long term goals/aspirations

I would like to develop a practice in which I work with a team of scientists and biomedical engineers in the creation of novel devices and software to map cardiac arrhythmias. The dream would be to run the first in human tests of these diagnostic and treatment strategies.

Post MSTP Training dream job

After finishing med school, three years of internal medicine residency, three years of cardiology fellowship, two years of electrophysiology fellowship, and maybe some post-doc years thrown in there for fun, I hope to get hired as an electrophysiologist at a large academic center with an 80%/30% clinical to research split.

FUN FACTS

What you enjoy outside of school?

I enjoy Netflix movies, plein air painting, and Overwatch.

A talent you have always wanted:

Anything musical.

Favorite book:

The Count of Monte Cristo by Alexander Dumas

Favorite quote:

“You can never be overdressed or overeducated..” –Oscar Wilde

Can’t live without …

Can’t live without trees. Applied to be an astronaut for Mars One, but in reality I couldn’t leave all the beautiful greens and blues behind (also they rejected me).

If you weren’t in MSTP, what would you be doing now?

I would like to think in a different life I could pursue a career as a painter, but the lack of job security and need for public approval would stress me out too much.

Awards, honors, publications

  • 1st place Winner of the Cardiac Electrophysiology Society Young Investigator Award, 2017
  • The Ohio State University Board of Trustees Student Recognition Award, December 2018
  • Nishikawara Graduate Student Scholar Award, Department of Physiology and Cell Biology, The Ohio State University College of Medicine, 2019
  • Nishikawara Graduate Student Scholar Award, Department of Physiology and Cell Biology, The Ohio State University College of Medicine, 2018
  • Ruth L. Kirschstein National Research Service Award F30 Fellowship, 1F30HL142179, NHLBI, Aug 2018- Aug 2022
  • Hansen BJ, Zhao J, Helfrich KM, Li N, Iancau A, Zolotarev A, Zakharkin SO, Kalyanasundaram A, Subr M, Dastagir N, Sharma R, Artiga E, Salgia N, Houmsse MM, Kahaly O, Janssen PML, Mohler PJ, Mokadam NA, Whitson B, Afzal MR, Simonetti OP, Hummel JD, Fedorov VV. Unmasking arrhythmogenic hubs of reentry driving persistent atrial fibrillation for patient-specific treatment. J Am Heart Assoc. 2020:e017789. PMID: 33006292.
  • Zolotarev AM, Hansen BJ, Ivanova EA, Helfrich KM, Li N, Jansen PML, Mohler PJ, Mokadam NA, Whitson B, Fedorov MV, Hummel JD, Dylov DV, Fedorov VV. Optical Mapping-Validated Machine Learning Improves Atrial Fibrillation Driver Detection by Multi-Electrode Mapping. Circ Arhythm Electrophysiol 2020. In Press. PMID: 32921129.
  • Mikhailov AV, Kalyanasundaram A, Li N, Scott SS, Artiga EJ, Subr MM, Zhao J, Hansen BJ, Hummel JD, Fedorov VV. Comprehensive evaluation of electrophysiological and 3D structural features of human atrial myocardium with insights on atrial fibrillation maintenance mechanisms. J Mol Cell 2020; In Press. PMID: 33130148.
  • Yanni J, D’Souza A, Wang Y, Li N, Hansen BJ, Zakharkin SO, Smith M, Hayward C, Whitson BA, Mohler PJ, Jansen PML, Zeef L, Choudhury M, Zi M, Cai X, Logantha SJ, Nakao S, Atkinson A, Petkova M, Doris U, Ariyaratnam J, Cartwright EJ, Griffiths-Jones S, Hart G, Fedorov VV, Oceandy D, Dobrzynski H, Boyett MR. Silencing miR-370-3p rescues funny current and sinus node function in heart failure. Sci Rep 2020;10:11279. PMID: 32647133.
  • Li N*, Kalyanasundaram A*, Hansen BJ*, Artiga EJ, Sharma R, Abudulwahed SH, Helfrich KM, Rozenberg G, Wu P, Zakharkin S, Gyorke S, Janssen PML, Whitson B, Mokadam NA, Biesiadecki BJ, Accornero F, Hummel JD, Mohler PJ, Dobrzynski H, Zhao J, Fedorov VV. Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node. Nat Commun 2020;11(1):512. PMID: 31980605. *Co-first authors.
  • Wang Y, Xiong Z, Nalar A, Hansen BJ, Kharche S, Seemann G, Loewe A, Fedorov VV, Zhao J. A Robust Computational Framework for Estimating 3D Bi-Atrial Chamber Wall Thickness. Comput Biol Med 2019;114:103444. PMID: 31542646.
  • Hansen BJ, Zhao J, Li N, Zolotarev A, Zakharkin S, Wang Y, Atwal J, Kalyanasundaram A, Abudulwahed SH, Helfrich KM, Bratasz A, Powell KA, Whitson B, Mohler PJ, Janssen PML, Simonetti OP, Hummel JD, Fedorov VV. Human Atrial Fibrillation Drivers Resolved with Integrated Functional and Structural Imaging to Benefit Clinical Mapping. J Am Coll Cardiol EP 2018;4(12):1501-15. PMID: 30573112.
  • Hansen BJ, Li N, Helfrich KM, Abudulwahed SH, Artiga E, Joseph M, Mohler PJ, Hummel JD, Fedorov VV. First In-vivo Use of High-Resolution Near-Infrared Optical Mapping to Assess Atrial Activation during Sinus Rhythm and Atrial Fibrillation in a Large Animal Model. Circ Arrhythm Electrophysiol 2018:11(12):e006870. PMID: 30562105
  • Kalyanasundaram A, Li N, Hansen BJ, Zhao J, Fedorov VV. Canine and Human Sinoatrial Node: Differences and Similarities in Structure, Function, Molecular Profiles and Arrhythmia. J Vet Cardiol 2019;22:2-19. PMCID: PMC6436970.
  • Li N*, Hansen BJ*, Csepe TA, Zhao J, Ignozzi AJ, Sul LV, Zakharkin SO, Kalyanasundaram A, Davis JP, Biesiadecki BJ, Kilic A, Janssen PML, Mohler PJ, Weiss R, Hummel JD, Fedorov VV. Redundant and Diverse Intranodal Pacemakers and Conduction Pathways Protect the Human Sinoatrial Node from Failure. Sci Transl Med. 2017;9(400):eaam5607. PMCID: PMC5775890. *Co-first authors.
  • Zhao J, Hansen BJ, Yufeng Wang, Csepe TA, Sul LV, Tang A, Yuan Y, Li N, Bratasz A, Powell KA, Kilic A, Mohler PJ, Janssen PML, Weiss R, Simonetti OP, Hummel JD, Fedorov VV. Three-dimensional Integrated Functional, Structural, and Computational Mapping to Define the Structural “Fingerprints” of Heart-Specific Atrial Fibrillation Drivers in Human Heart Ex-Vivo. J Am Heart Assoc. 2017;6(8):e005922. PMCID: PMC5586436.
  • Csepe TA, Zhao J, Sul LV, Wang Y, Hansen BJ, Li N, Ignozzi AJ, Bratasz A, Powell KA, Kilic A, Mohler PJ, Janssen PML, Hummel JD, Simonetti OP, Fedorov VV. Novel Application of 3D Contrast-Enhanced CMR to Define Fibrotic Structure of the Human Sinoatrial Node In Vivo. Eur Heart J Cardiovasc Imaging 2017;18(8):862-9. PMCID: PMC5837534.
  • Hansen BJ, Zhao J, Fedorov VV. Fibrosis and Atrial Fibrillation: Computerized and Optical Mapping; A View into the Human Atria at Submillimeter Resolution. J Am Coll Cardiol EP 2017;3(6):531-546. PMCID: PMC5693365.
  • Fedorov VV, Hansen BJ. Now You See a Rotor, Now You Don’t. J Am Coll Cardiol EP 2017;4(1):84-6. DOI: 10.1016/j.jacep.2017.09.176
  • Fedorov VV, Hansen BJ. A Secret Marriage Between Fibrosis and Atrial Fibrillation Drivers. J Am Coll Cardiol EP 2017;4(1):30-2. DOI: 10.1016/j.jacep.2017.08.014
  • Hansen BJ, Csepe TA, Zhao J, Ignozzi AJ, Hummel JD, Fedorov VV. Maintenance of Atrial Fibrillation: Are Reentrant Drivers with Spatial Stability the Key? Circ Arrhythm Electrophysiol 2016; 9(10):e004398. PMCID: PMC5066578
  • Li N, Csepe TA, Hansen BJ, Sul LV, Kayanasundaram A, Zakharkin SO, Zhao J, Guha A, Van Waoner DR, Kilic A, Moler PJ, Janssen P ML, Biesiadecki BJ, Hummel JD, Weiss R, Fedorov VV. Adenosine-Induced Atrial Fibrillation: Localized Reentrant Drivers in Lateral Right Atria due to Heterogeneous Expression of Adenosine A1 Receptors and GIRK4 Subunits in the Human Heart. Circulation. 2016; 134(6):486-98. PMCID: PMC4980184.
  • Csepe TA, Hansen BJ, Fedorov VV. Atrial Fibrillation Driver Mechanisms: Insights from the Isolated Human Heart. Trends Cardiovas Med 2017; 27(1):1-11. PMCID: PMC5122472.
  • Shettigar V, Zhang B, Little SC, Salhi HE, Hansen BJ, Li N, Zhang J, Roof SR, Ho HT, Brunello L, Lerch JK, Weisleder N, Fedorov VV, Accornero F, Rafael-Fortney JA, Gyorke S, Janssen PM, Beisiadecki BJ, Ziolo MT, Davis JP. Rationally Engineered Troponin C Modulates In Vivo Cardiac Function and Performance in Health and Disease. Nat Commun 2016; 7:10794. PMCID: PMC4770086.
  • Csepe TA, Zhao J ,Hansen BJ, Li N, Sul LV, Lim P, Wang Y, Simonetti OP, Kilic A, Mohler PJ, Janssen PML, Fedorov VV. Human Sinoatrial Node Structure: 3D Microanatomy of Sinoatrial Conduction Pathways. Prog Biophys Mol Bio. 2015; 120:164-178. PMCID: PMC4808362.
  • Hansen BJ, Zhao J, Csepe TA, Moore BT, Li N, Jayne LA, Kalyanasundaram A, Lim P, Bratasz A, Powell KA, Simonetti O, Higgins RSD, Kilic A, Mohler PJ, Janssen PML, Weiss R, Hummel JD, Fedorov VV. Atrial Fibrillation Driven by Microanatomic Intramural Reentry Revealed by Simultaneous Sub-Epicardial and Sub-Endocardial Optical Mapping in Explanted Human Hearts. Eur Heart J 2015; 36(35):2390-2401. PMCID: PMC4568403.
  • Li N, Csepe TA, Hansen BJ, Dobrizynski H, Higgins RSD, Killic A, Mohler PJ, Janssen PML, Rosen MR, Biesiadecki BJ, Fedorov VV. Molecular Mapping of Sinoatrial Node HCN Channel Expression in the Human Heart. Circ Arrhythm Electrophysiol 2015; 8(5):1219-1227. PMCID: PMC4618238.
  • Zhao J, Hansen BJ, Csepe TA, Lim P, Wang Y, Williams M, Mohler PJ, Janssen PML, Weiss R, Hummel JD, Fedorov VV. Integration of High Resolution Optical Mapping and 3D Micro-CT Imaging to Resolve the Structural Basis of Atrial Conduction in the Human Heart. Circ Arrhythm Electrophysiol 2015; 8(6):1514-1517. PMC4683613.
  • Zhao J, Kharche SR, Hansen BJ, Csepe TA, Wang Y, Stiles MK, Fedorov VV. Optimization of Catheter Ablation of Atrial Fibrillation: Insights Gained from Clinically-Derived Computer Models. Int. J. Mol. Sci. 2015; 16: 10834-10854. PMCID: PMC4463678.
  • Csepe TA, Kalyanasundaram A, Hansen BJ, Zhao J, Fedorov VV. Fibrosis: A structural modulator of sinoatrial node physiology and dysfunction. Front. Physiol. 2015; 6:37. PMCID: PMC4325882.
  • Lou Q*, Hansen BJ*, Fedorenko O, Csepe TA, Kalyanasundaram A, Li N, Hage LT, Glukhov AV, Billman GE, Weiss R, Mohler PJ, Györke S, Biesiadecki BJ, Carnes CA, Fedorov VV. Upregulation of Adenosine A1 Receptors Facilitates Sinoatrial Node Dysfunction in Chronic Canine Heart Failure by Exacerbating Nodal Conduction Abnormalities Revealed by Novel Dual-Sided Intramural Optical Mapping. Circulation 2014; 130:315-324. PMCID: PMC4323163. *Co-first authors.
  • Lou Q, Glukhov AV, Hansen B, Hage L, Vargas-Pinto P, Billman GE, Carnes CA, Fedorov VV. Tachy-brady arrhythmias: the critical role of adenosine-induced sinoatrial conduction block in post tachycardia pauses. Heart Rhythm 2013; 10(1):110-8. PMCID: PMC3858187.
  • Glukhov AV, Kalyanasundaram A, Lou Q, Hage LT, Hansen BJ, Belevych AE, Mohler PJ, Knollmann BC, Periasamy M, Györke S, Fedorov VV. Calsequestrin 2 deletion causes sinoatrial node dysfunction and atrial arrhythmias associated with altered sarcoplasmic reticulum calcium cycling and degenerative fibrosis within the mouse atrial pacemaker complex. Eur Heart J 2013; 36(11):686-697. PMCID: PMC4359358.
  • Glukhov AV, Hage LT, Hansen BJ, Pedraza-Toscano A, Vargas-Pinto P, Hamlin RL, Weiss R, Carnes CA, Billman GE, Fedorov VV. Sinoatrial node reentry in a canine chronic left ventricular infarct model: role of intranodal fibrosis and heterogeneity of refractoriness. Circ Arrhythm Electrophysiol 2013; 6(5):984-994. PMCID: PMC3904863.
  • Hansen BJ, Csepe TA, Fedorov VV. Section 4 – Cell Biology of Cardiac Impulse Initiation and Propagation: Mechanisms of Normal and Dysfunctional Sinoatrial Nodal Excitability and Propagation. Cardiac Electrophysiology: From Cell to Bedside, 7th Edition. Elsevier, 2016.

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