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Student Spotlight - Wenyuan (Ren) Yin

Marcus Harrigan 

Wenyuan (Ren) Yin
Louisville, KY



Research interests:

I am interested in studying bidirectional communication between the CNS and immune systems, especially in the context of social stress. My work focuses on how the immune-brain axis contributes to the development of behavioral changes (e.g. anxiety- and depressive-like behaviors) following psychosocial stress. I use a mouse model of chronic psychosocial stress called Repeated Social Defeat.

Awards, honors, publications:

Ohio State University – University Fellowship (2018-2019)


Publications (at OSU):

Michael D Weber, Daniel B McKim, Anzela Niraula, Kristina G Witcher, Wenyuan Yin, Carly G Sobol, Yufen Wang, Caroline M Sawicki, John F Sheridan, Jonathan P Godbout. Reply to Microglia, Monocytes, and the Recurrence of Anxiety in Stress-Sensitized Mice. Biol Psychiatry. In press.

Wenyuan Yin, Natalie R Gallagher, Caroline M Sawicki, Daniel B McKim, Jonathan P Godbout, John F Sheridan. Repeated Social Defeat in Female Mice Induces Anxiety-Like Behavior Associated with Enhanced Myelopoiesis and Increased Monocyte Accumulation in the Brain. Brain, Behavior, and Immunity. 2019 Jan 23. doi: 10.1016/j.bbi.2019.01.015

Daniel B McKim, Wenyuan Yin, Yufen Wang, Steve W Cole, Jonathan P Godbout, John F Sheridan. Social Stress Mobilizes Hematopoietic Stem Cells to Establish Persistent Splenic Myelopoiesis. Cell Rep. 2018 Nov 27; 25(9). doi:10.1016/j.celrep.2018.10.102

Michael D Weber, Daniel B McKim, Anzela Niraula, Kristina G Witcher, Wenyuan Yin, Carly G Sobol, Yufen Wang, Caroline M Sawicki, John F Sheridan, Jonathan P Godbout. The Influence of Microglial Elimination and Repopulation on Stress-Sensitization Induced by Repeated Social Defeat. Biol Psychiatry. 2018 Oct 25. doi: 10.1016/j.biopsych.2018.10.009

Publications (before OSU):

Wenyuan Yin, Charles W. Kimbrough, Jorge G. Gomez-Gutierrez, Christopher T. Burns, Phillip Choung, William E. Grizzle, Lacey R. McNally. Tumor specific liposomes improve detection of pancreatic adenocarcinoma in vivo using Optoacoustic Tomography. J Nanobiotechnology. 2015 Dec 1; 13:90. doi: 10.1186/s12951-015-0139-8.

Shanice V. Hudson, Justin S. Huang, Wenyuan Yin, Sabrin Albeituni, Jamie Rush, Anil Khanal, Jun Yan, Brian P. Ceresa, Hermann B. Frieboes, Lacey R. McNally. Targeted Noninvasive Imaging of EGFR-Expressing Orthotopic Pancreatic Cancer Using Multispectral Optoacoustic Tomography. Cancer Res. 2014 Nov 1;74(21):6271-9. doi: 10.1158/0008-5472

Hermann B. Frieboes, Justin S. Huang, Wenyuan Yin, Lacey R. McNally. Chloroquine-mediated cell death in metastatic pancreatic adenocarcinoma through inhibition of autophagy. JOP. 2014 Mar 10;15(2):189-97. doi: 10.6092/1590-8577/1900

Michael E. Egger, Justin S. Huang, Wenyuan Yin, Kelly M. McMasters, Lacey R. McNally. Inhibition of autophagy with chloroquine is effective in melanoma. J Surg Res. 2013 Sep;184(1):274-81. doi: 10.1016/j.jss.2013.04.055

​Long term goals/aspirations:

I haven’t decided which specialty I’d like to pursue, but I imagine I’d end up working mostly inpatient, with an emphasis on clinical research. I’d like to spend most of my time designing or conducting clinical trials, especially for management of chronic pain.

​Post MSTP Training dream job:

I’d like to be an attending physician somewhere with more pleasant weather than the Midwest. Northern California, perhaps! I haven’t worked out any of the other details yet.


What you enjoy outside of school:

I really enjoy spending as much time outside as possible when the weather is warm. In the spring and summer, I take my dog to all the parks around Columbus so she can sniff all the trees. I like hiking in state and national parks (trying to visit as many as I can in my 20s). I also love cooking, baking, and making craft cocktails including my own liquers and flavored syrups.

A talent you have always wanted:

I wish I could sing (well)! I’m sorry to those of you who have/will have suffered a long car ride with me at any point.

Favorite quote:

     “You can never be overdressed or overeducated.” – Kate Spade


Favorite book:

     The Harry Potter series will forever have a special place in my heart. I’m currently reading Salt, Fat, Acid, Heat by Samin Nosrat

Can't live without:

Animals! Especially my going-on-13 Pomeranian, Mercedes. She’s an absolute princess and has been my best friend for over a decade.

If you weren't in MSTP, what would you be doing now?

If I had been better at math and physics, I might have been an engineer.