About Us 

From bench to bedside, the Gumina lab is deciphering the role of extracellular nucleotide metabolism in human cardiovascular disease.

Dr. Gumina is a physician-scientist (MD, PhD) interventional cardiologist with an active research program examining the role of extracellular nucleotide regulation in cardiovascular disease.

The laboratory is focused on understanding the molecular mechanisms that influence the levels of extracellular ATP, ADP and adenosine following vascular or myocardial injury. 

We have identified novel human polymorphisms that modulate extracellular nucleotide metabolism. The overall goal of this work is to understand how innate regulation of extracellular nucleotide/nucleoside metabolism controls normal cardiac physiology and modifies myocardial injury and healing in human pathology. 

With the insights gained through these investigations we will develop novel approaches, diagnostics and therapies to improve the treatment of patients with acute coronary syndromes and atherosclerotic cardiovascular disease.

Lab Members

Staff
Emilee Gaitten, BA
Oscar Bermeo-Blanco, DVM

Postdoctoral Fellows
Shamama Nishat, PhD
Avirup Chakraborty, PhD
Roman Covarrubias, PhD

Graduate Students
Samuel Watson, BS

Medical Students
Kyle Gordon, BS

Publications

https://www.ncbi.nlm.nih.gov/pubmed/?term=gumina+rj

Research Projects

Project 1: The role of nucleotidases in myocardial injury.

Project 2: The role of nucleotidases in arterial injury and thrombosis.

Project 3: The interaction of nucleotidases and the ATP sensitive potassium channel in modulating ischemic injury.

Project 4: The Ohio State University Cardiovascular Medicine Biorepository. 

Research Openings

Postdoctoral Fellow

A postdoctoral position is available immediately in the Division of Cardiovascular Medicine to study the fundamental role of nucleotidases in cardiovascular disease. Small laboratory animal models, biochemistry, molecular biology and proteomics techniques are the main research approaches for these studies, complemented by human studies. The successful applicant will hold a PhD and/or an MD with two years of postdoctoral experience. Expertise in either platelet biology or cardiomyocyte biology combined with proficiency in both biochemical assays and molecular biology are necessary. Ability to work both independently and cooperatively within a team is essential. The successful candidate should demonstrate excellent scientific communication, presentation and writing skills, and analytical problem-solving skills as well as a strong work ethic. Funding for the position is available for one year with the possibility of extension. Salary is dependent upon the applicant’s experience and follows National Institutes of Health guidelines.

Please forward CV to Dr. Gumina directly at: richard.gumina@osumc.edu

Graduate Student

A graduate student position is available to study the fundamental role of nucleotidases in cardiovascular disease. Small laboratory animal models, biochemistry, molecular biology and proteomics techniques are the main research approaches for these studies, complemented by human studies. 

Students should contact Dr. Gumina directly at: richard.gumina@osumc.edu

Collaborators

Robson Lab
Bansal Lab
Nimjee Lab

Contact

Mailing address
Gumina Lab
Davis Heart and Lung Research Institute
Room 635
473 W. 12th Ave.
Columbus, OH 43210

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