About Us

The Acute Lung Injury (ALI) Center, directed by Rama Mallampalli, MD, is a specialized research center focused on understanding the basic lung biology of pulmonary inflammation and development of novel therapeutics. Through collaborative projects involving clinical faculty and experts in lung biology, the laboratory spans the spectrum of discovery including basic, translational and clinical research.

Dr. Mallampalli is an internationally recognized investigator in the area of lipid metabolism and ubiquitin-mediated proteolysis as it relates to inflammation lung injury and cell metabolism. His research program discovered a unique model for the molecular behavior of ubiquitin E3 ligase subunits that control inflammation. Dr. Mallampalli’s laboratory designed, synthesized and tested the first-in-class genus of ubiquitin E3 ligase (F box) inhibitors that modulate proteolysis thereby inhibiting inflammation in preclinical models of ALI and multi-organ failure. He currently leads an NIH Program Project grant (P01) in ALI and holds multiple NIH R01 grants to understand the basic pathobiology of inflammatory lung disease to develop drug therapies to combat injurious inflammation.

Lab Members

Mallampalli Lab Team

Faculty

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Rama Mallampalli, MD

  • S. Robert Davis Chair of Medicine
    Professor and Chair, Department of Internal Medicine
    Director, ALI Center
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James Londino, PhD

  • Assistant Professor of Medicine
    Associate Director, ALI Center
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Joseph Bednash, MD

  • Assistant Professor of Medicine
    Assistant Director, ALI Center

Staff

Daniela Farkas
Lab Manager

Jessica Adair
Research Associate

Ajit Elhance
Research Assistant

Finny Johns
Research Assistant

Wissam Osman
Research Assistant

Lexie Chafin
Research Assistant

Benjamin Johnson
Graduate Student

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More about the Acute Lung Injury (ALI) Center

More about the Acute Lung Injury (ALI) Center

Research Openings

Research Openings

Collaborators

Richard Robinson

Richard Robinson, PhD

  • Associate Professor, Department of Microbial Infection and Immunity
Laszlo Farkas

Laszlo Farkas, MD

  • Associate Professor of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine

External Collaborators

Valerian Kagan

Valerian Kagan, PhD, DSc

  • Professor, Environmental and Occupational Health
    Vice Chair of Research, Environmental and Occupational Health
    University of Pittsburgh
Lee

Janet So-Jung Lee, MD

  • Pulmonary, Allergy and Critical Care Medicine
    Professor of Medicine
    Director, Acute Lung Injury Center of Excellence, UPMC Chair in Acute Lung Injury
    University of Pittsburgh
Prabir Ray

Prabir Ray, PhD

  • Pulmonary, Allergy and Critical Care Medicine
    Professor of Medicine and Immunology
    UPMC Endowed Chair in Lung Immunology
    University of Pittsburgh
Anuradha Ray

Anuradha Ray, PhD

  • Pulmonary, Allergy and Critical Care Medicine
    Professor of Medicine and Immunology
    UPMC Endowed Chair in Lung Immunology
    University of Pittsburgh

Contact Information

Daniela Farkas
Lab Manager
Daniela.farkas@osumc.edu

Mallampalli Lab
Davis Heart and Lung Research Institute
Room 524/525
473 W. 12th Ave.
Columbus, OH 43210

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