Rama Mallampalli, MD
- S. Robert Davis Chair of Medicine Professor and Chair, Department of Internal Medicine Director, ALI Center
The Acute Lung Injury (ALI) Center, directed by Rama Mallampalli, MD, is a specialized research center focused on understanding the basic lung biology of pulmonary inflammation and development of novel therapeutics. Through collaborative projects involving clinical faculty and experts in lung biology, the laboratory spans the spectrum of discovery including basic, translational and clinical research.
Dr. Mallampalli is an internationally recognized investigator in the area of lipid metabolism and ubiquitin-mediated proteolysis as it relates to inflammation lung injury and cell metabolism. His research program discovered a unique model for the molecular behavior of ubiquitin E3 ligase subunits that control inflammation. Dr. Mallampalli’s laboratory designed, synthesized and tested the first-in-class genus of ubiquitin E3 ligase (F box) inhibitors that modulate proteolysis thereby inhibiting inflammation in preclinical models of ALI and multi-organ failure. He currently leads an NIH Program Project grant (P01) in ALI and holds multiple NIH R01 grants to understand the basic pathobiology of inflammatory lung disease to develop drug therapies to combat injurious inflammation.
Davis Heart and Lung Research Institute
473 W. 12th Ave.
Columbus, OH 43210