Recent Highlights
Peter Lee, MD, PhD, MPH, received a K08 award from National Institute of General Medical Sciences for “Tissue Engineered Skeletal Muscle Delivering a Myokine Protein to Treat Volumetric Muscle Loss.”
Bryan Whitson, MD, PhD, will receive a new R01 grant from National Heart, Lung, and Blood Institute on the topic of “Preservation and Rescue of the Lung Donor Allograft for Transplantation.”
Renzhi Han, PhD,.received his first R01 competitive renewal from the National Heart, Lung, and Blood Institute on the topic of “Ano5 in Muscle Health and Disease,” which earned a fundable score of 13%. View PubMed
Renzhi Han, PhD's work on two novel rabbit models of muscular dystrophy were published in Disease Models and Mechanisms and Cell Death and Disease, respectively.
View PubMed
Hua Zhu, PhD, recently had two papers accepted by Acta Pharmacologica Sinica and Cellular Physiology and Biochemistry regarding cancer immune checkpoint blockade therapy and activating Akt/NOS to inhibit autophagy and promote angiogenesis, respectively. View PubMed
Kristyn Gumpper, a graduate student in Dr. Ma’s laboratory, received a pre-doctoral fellow from the American Heart Association.
Wesolowski R, Duggan MC, Stiff A, Markowitz J, Trikha P, Levine KM, Schoenfield L, Abdel-Rasoul M, Layman R, Ramaswamy B, Macrae ER, Lustberg MB, Reinbolt RE, Mrozek E, Byrd JC, Caligiuri MA, Mace TA, Carson WE 3rd. Circulating myeloid-derived suppressor cells increase in patients undergoing neo-adjuvant chemotherapy for breast cancer. Cancer Immunol Immunother. 2017 Nov;66(11):1437-1447. doi: 10.1007/s00262-017-2038-3. Epub 2017 Jul 7. PubMed PMID: 28688082; PubMed Central PMCID: PMC5647220. PubMed.
Pyter LM, Suarez-Kelly LP, Carson WE 3rd, Kaur J, Bellisario J, Bever SR. Campbell AR, Duggan MC, Bhave N, Opheim KS, McMichael EL, Trikha P, Parihar R, Luedke E, Lewis A, Yung B, Lee R, Raulet D, Tridandapani S, Groh V, Yu L, Yildiz V, Byrd JC, Caligiuri MA. MICA-expressing monocytes enhance natural killer cell Fc receptor-mediated antitumor functions. Cancer Immunol Res. 2017 Sep;5(9):778-789. doi: 10.1158/2326-6066.CIR-16-0005. Epub 2017 Jul 19. PubMed PMID: 28724544; PubMed Central PMCID: PMC5581690. PubMed.
Duggan MC, Stiff AR, Bainazar M, Regan K, Olaverria Salavaggione GN, Maharry S, Blachly JS, Krischak M, Walker CJ, Latchana N, Tridandapani S, de la Chapelle A, Eisfeld AK, Carson WE 3rd. Identification of NRAS isoform 2 overexpression as a mechanism facilitating BRAF inhibitor resistance in malignant melanoma. Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):9629-9634. doi: 10.1073/pnas.1704371114. Epub 2017 Aug 21. PubMed PMID: 28827320; PubMed Central PMCID: PMC5594655. PubMed.
Wesolowski R, Duggan MC, Stiff A, Markowitz J, Trikha P, Levine KM, Schoenfield L, Abdel-Rasoul M, Layman R, Ramaswamy B, Macrae ER, Lustberg MB, Reinbolt RE, Mrozek E, Byrd JC, Caligiuri MA, Mace TA, Carson WE 3rd. Circulating myeloid-derived suppressor cells increase in patients undergoing neo-adjuvant chemotherapy for breast cancer. Cancer Immunol Immunother. 2017 Nov;66(11):143. PubMed.
Stiff A, Trikha P, Mundy-Bosse B, McMichael E, Mace TA, Benner B, Kendra K, Campbell A, Gautam S, Abood D, Landi I, Hsu V, Duggan M, Wesolowski R, Old M, Howard JH, Yu L, Stasik N, Olencki T, Muthusamy N, Tridandapani S, Byrd JC, Caligiuri M, Carson WE. Nitric oxide production by myeloid-derived suppressor cells plays a role in impairing Fc receptor-mediated natural killer cell Function. Clin Cancer Res. 2018 Apr 15;24(8):1891-1904. PubMed.
Lai X, Stiff A, Duggan M, Wesolowski R, Carson WE 3rd, Friedman A. Modeling combination therapy for breast cancer with BET and immune checkpoint inhibitors. Proc Natl Acad Sci U S A. 2018 May 22;115(21):5534-5539. PubMed.
Buteyn NJ, Fatehchand K, Santhanam R, Fang H, Dettorre GM, Gautam S, Harrington BK, Henderson SE, Merchand-Reyes G, Mo X, Benson DM, Carson WE 3rd, Vasu S, Byrd JC, Butchar JP, Tridandapani S. Anti-leukemic effects of all-trans retinoic acid in combination with Daratumumab in acute myeloid leukemia. Int Immunol. 2018 Jun 2. PubMed.
Hu Z, Shen R, Campbell A, McMichael E, Yu L, Ramaswamy B, London CA, Xu T, Carson WE 3rd. Targeting tissue factor for immunotherapy of triple-negative breast cancer using a second-generation ICON. Cancer Immunol Res. 2018 Jun;6(6):671-684. PubMed.