Clinical research enables our medical professionals to understand mechanisms that lead to new solutions. Once those solutions are developed, clinical trials ensure they are safe and ready for use among those who need them.

Our Highlights


Finding targeted drugs to turn off suppressor cells

Despite the promising results of immune-based therapies in treating cancer, almost 70 percent of patients with advanced cancers do not respond to a new class of immune-stimulating drugs. Dr. Carson’s research group feels that this lack of response could be due to a type of immune cell that the cancer uses to block tumor shrinkage. These suppressor cells can be turned off or even eliminated with targeted drugs. Dr. Carson and his group are now conducting clinical studies in patients with cancer using a combination of drugs: one drug to stimulate the cancer fighters of the immune system and another to block the suppressor cells. These studies are first piloted as test tube experiments and then later taken into the clinic to help patients.

Learn more about Dr. William Carson

Creating systems and environments to ensure the highest level patient care

A Learning Healthcare System (LHS) can be described as an organizational approach to healthcare delivery with efforts to improve both the effectiveness and the quality of outcomes and efficiency. For an LHS to be effective, research must be integral to the operations so that a continuous cycle of implementation, study and improvement is embraced.

The Institute for the Design of Environments Aligned for Patient Safety (IDEA4PS) was created to leverage the LHS concept and provide the highest level of care to our patients locally as well as nationally.
Dr. Poulose presenting

Working to restore abdominal core health in surgery patients

Maintaining abdominal core health is important to nearly every activity we perform in our daily lives. Yet abdominal core strength and integrity can be compromised by life-saving operations needed for trauma, transplantation, cancer or other diseases requiring abdominal surgery. Dr. Benjamin Poulose’s research efforts focus on restoring abdominal core health in patients by identifying the best treatments for hernia and related pain and weakness of the abdominal core.

Learn more about Dr. Benjamin Poulose

Using infrared to better see parathyroids

Parathyroids are tiny organs located next to the thyroid glands. These organs are vital for calcium hemostasis, which manages calcium levels in the body. Dr. John Phay’s laboratory discovered that parathyroids naturally “glow” in the near-infrared spectrum, allowing them to be more easily seen during surgery. This facilitates their preservation during surgery for thyroid cancer, for example. And if the parathyroids are diseased, they’re easily seen for removal.

Learn more about Dr. John Phay
operating room

Reducing significant swelling following tumor removal

A cluster of lymph nodes from the intestines is helping restore the quality of life to patients who experience cancer surgery and develop swelling known as lymphedema in the arms or legs. Dr. Daniel Eiferman and Dr. Roman Skoracki of the OSU Lymphedema Center of Excellence, pioneered a new surgery to reduce life-style inhibiting swelling that can occur after tumor removal. Rather than taking lymph nodes from a “good” arm or leg and transplanting them to the affected area — the standard surgical procedure for lymphedema that increases the patient’s risk for developing the disorder in the previously unaffected limb — they learned they could take lymph nodes that drain the small intestine without negatively impacting the intestine.

Learn more about Dr. Daniel Eiferman