I studied medicine in the Medical School of Athens University (in Athens, Greece). After obtaining my medical doctorate degree, I fulfilled my military service as a Sergeant M.D. of the Greek Airforce. My strong will to train as both a researcher and a clinician in the field of Hematology/Oncology led me leave Greece, as in my home country physician training is exclusively clinical. In search of an academic institution where I could combine training in experimental and clinical medicine, I applied for a position at the Freiburg University Medical Center in Germany. I was awarded an internal scholarship and was accepted as a research fellow at the institution. I joined the Research Group of Dr. Hendrik Veelken, who was then the Leading Physician of the Research Department. Together, we studied the capacity of the immune system to identify tumor-specific antigens of malignant lymphoid clones and to mount anti-tumor responses. This work was the basis of my thesis for the acquisition of the German medical doctorate degree, which I was awarded with the distinction of magna cum laude. It was also included in two independent publications in Blood and Haematologica. With Prof. Veelken’s recommendation, I was offered a position in the physician training program of the Freiburg University, where I completed annual rotations in the acute leukemia and the bone marrow transplantation units. This was a very challenging and rewarding experience that reaffirmed my will to combine translational research with clinical work. It also allowed me to expand my research focus and develop an interest in the biology and treatment of myeloid malignancies. With the kind assistance and support of my supervisors at the Freiburg University Medical Center, I was given the opportunity to continue my research training in the United States of America. I joined the research group of Dr. Clara D. Bloomfield at The Ohio State University in November of 2012. Since July of 2014 Dr. Ramiro Garzon has also actively participated in my mentorship. Together we have co-authored six published articles, which are mainly focused on the prognostic and biologic significance of non-coding RNAs in acute myeloid leukemia. We were the first to report on long non-coding RNA signatures that associate with clinical outcome of younger and older AML patient. We have also studied the biologic function of individual lncRNAs and have reported on the role of a HOXB-locus embedded lncRNA in ribosome biogenesis. Given my will to resume my clinical training, the Physician Scientist Training Program that The Ohio State University offers provided an excellent opportunity to pursue both of my career goals. I was fortunate enough to be accepted in the program and start my work as a resident physician in the Department of Internal Medicine in June of 2018. The experience has so far been extremely gratifying. The Ohio State University Wexner Medical Center offers an excellent environment for clinical training. A wide variety of complex cases are seen and treated here, as OSUWMC is a referral center for a number of disease entities. The quality of the provided healthcare is outstanding as well as the supervision and teaching from experienced faculty. In addition, the functional relationships between the residents and the level of help and support that one gets fromone’s peers are truly remarkable. This is not a random feature; the faith in joined work and the culture of mutual support between the members of the team are embedded in the character of the institution and are indispensable parts of the Buckeye identity. With regard to the city itself, Columbus is a very charming, welcoming, and vibrant place. It is the home of a growing community of young professionals and students, who shape the city’s character and every-day life. Columbus combines the attractions and the variety of options regarding culture and entertainment of a Metropole with the personality and warmth of a mid-Western city. It is a place one can fall in love with and easily call home.
Bill M, Papaioannou D, Karunasiri M, Kohlschmidt J, Walker AE, Brannan Z, Mrózek K,
LaRocco A, Volinia S, Bloomfield CD, Garzon R, Dorrance AM. Expression and functional
relevance of long non-coding RNAs in acute myeloid leukemia stem cells. Leukemia
Mrózek K, Eisfeld AK, Kohlschmidt J, Carroll AJ, Walker CJ, Blachly JS, Bill M,
Papaioannou D, Wang ES, Uy GL, Kolitz JE, Powell BL, Stone RM, Byrd JC, Bloomfield
CD. Complex karyotype in acute myeloid leukemia: typical and atypical subtypes differ
molecularly and clinically. Leukemia
Papaioannou D, Petri A, Dovey OM, Terreri S, Wang E, Collins FA, Woodward LA,
Nicolet D, Kumchala P, Pepe F, Marius Bill M, Karunasiri M, Gardner M, Mrózek K,Zitzer
NC, Camilotto V., Cooper JL, Cai X, Rong-Mullins X, Kohlschmidt J, Archer KJ, Freitas
MA, Zheng Y, Lee R, Aifantis I, Vassiliou G., Singh G., Kauppinen S, Bloomfield CD,
Dorrance AM, Garzon R. The Long Non-Coding RNA HOXB-AS3 Regulates Ribosomal
RNA Transcription in NPM1-Mutated Acute Myeloid Leukemia. Nature Communications
Papaioannou D, Nicolet D, Hatice G Ozer, Mrózek K, Volinia S, Fadda P, Carroll AJ,
Kohlschmidt J, Kolitz JE, Wang ES, Stone RM, Byrd JC, Garzon R, Bloomfield CD.
Prognostic and Biologic Relevance of Clinically Applicable Long Non-Coding RNA
Profiling in Older Patients with Cytogenetically Normal Acute Myeloid Leukemia.
Molecular Cancer Therapeutics
Vasu S, Kohlschmidt J, Mrózek K, Eisfeld AK, Nicolet D, Sterling LJ, Becker H, Metzeler
KH, Papaioannou D, Powell BL, Kolitz JE, Moore JO, Baer MR, Roboz GJ, Stone RM,
Byrd JC, Carroll AJ, Bloomfield CD. Ten-year outcome of patients with acute myeloid
leukemia not treated with allogeneic transplantation in first complete remission. Blood
Advances 2018 2:1645-1650
- Papaioannou D, Nicolet D, Volinia S, Mrózek K, Yan P, Bundschuh R, Carroll AJ,
Kohlschmidt J, Blum W, Powell BL, Uy GL, Kolitzg JE, Wang ES, Eisfeld AK, Lucas DM,
Shelley O, Caligiuri MA, Stone RM, Byrd JC, Garzon R, Bloomfield CD. Prognostic and
biologic significance of long non-coding RNA profiling in younger adult patients with
cytogenetically normal acute myeloid leukemia. Haematologica. 2017 Aug;102(8):1391-
1400
- Papaioannou D, Shen C, Nicolet D, McNeil B, Karunasiri M, Matthew Burke, Gulcin
Ozer H, Yilmaz S, Behbehani G, Marcucci G, Powell B, Kolitz J, Carter T, Wang E, Mrozek
K, Caligiuri M, Bloomfield CD, Garzon R, Dorrance AD. Expression, Prognosis and
Mechanistic Insights of EGFL7 in Acute Myeloid Leukemia (AML) Proc Natl Acad Sci U
S A. 2017;114(23):E4641-E4647
- Leoncini PP, Bertaina A, Papaioannou D, Flotho C, Masetti R, Bresolin S, Menna G,
Santoro N, Zecca M, Basso G, Nigita G, Veneziano D, Pagotto S, D’Ovidio K, Rota R,
Dorrance AM, Croce CM, Niemeyer CM, Locatelli F, Garzon R. MicroRNA fingerprints
in Juvenile Myelomonocytic Leukemia (JMML) identified miR-150-5p as a tumor
suppressor and potential target for treatment. Oncotarget. 2016;(7):55395-55408
- Lai TH, Ewald B, Zecevic A, Liu C, Sulda M, Papaioannou D, Garzon R, Blachly JS,
Plunkett W, Sampath D. HDAC inhibition induces microRNA-182 which targets Rad51
and impairs HR repair to sensitize cells to sapacitabine in acute myelogenous leukemia.
Clin Cancer Res. 2016;22(14):3537-3549
- Papaioannou D, Strothmeyer AM, Dühren-von Minden M, Keppler-Hafkemeyer A,
Zirlik K, Mikesch K, van Bergen CA, Navarrete MA, Veelken H. Evidence for idiotypedirected immunosurveillance is restricted to follicular lymphoma and attributable to
somatic hypermutation. Haematologica. 2015;100(4):e143-e146.
- Garzon R, Volinia S, Papaioannou D, Nicolet D, Kohlschmidt J, Yan PS, Mrózek K,
Bucci D, Carroll AJ, Baer MR, Wetzler M, Carter TH, Powell BL, Kolitz JE, Moore JO,
Eisfeld AK, Blachly JS, Blum W, Caligiuri MA, Stone RM, Marcucci G, Croce CM, Byrd
JC, Bloomfield CD. Expression and prognostic impact of lncRNAs in acute myeloid
leukemia. Proc Natl Acad Sci U S A. 2014;111(52):18679-18684.
- Strothmeyer AM, Papaioannou D, Navarrete M, Zirlik K, Mikesch K, Veelken H.
Comparative analysis of predicted HLA binding of the immunoglobulin idiotype
sequences indicates T cell- mediated immunosurveillance in follicular lymphoma. Blood.
2010; 116(10):1734-1736
