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Daniel Wozniak, PhD


Professor, Department of Microbial Infection and Immunity
Professor, Department of Microbiology

Member, Center for Microbial Interface Biology ​

Courtesy appointment:  ​
Department of Infectious Diseases
 
Contact information:​
704 Biomedical Research Tower (BRT)
460 W 12th Ave, Columbus OH 43210
Phone: (614) 247-7629

Publications
 

Research Interests

The major goal of Dr. Wozniak's laboratory is to understand the molecular biology and pathogenesis of  Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus which are important human pathogens. Our research has centered on several key areas:

1.) Coordinate regulation of virulence gene expression
2.) Biofilm formation and pathogenesis
3.) Experimental therapeutics to combat infections
4.) Animal models of chronic infection
5.) Defining patho-adaptive processes and evolution of bacteria during infection.

Most chronic and recurrent human bacterial infections involve biofilms and treatment of these diseases cost the U.S. health care system billions of dollars annually. Bacteria within a biofilm demonstrate a substantially increased resistance to effectors of both innate and acquired immunity as well as to the action of antimicrobials. In collaboration with scientists at University of Washington and Toronto Hospital for Sick Children, we are exploiting the activity of enzymes that can break down the matrix allowing cells normally resistant to therapies to become more amenable to treatment. In addition our studies with Medimmune seek to use human monoclonal antibodies that target one biofilm matrix component in treatments of patients colonized with biofilm forming bacteria. Finally, we are working with colleagues in the OSU Comprehensive Wound Care Center to implement new therapies aimed at disrupting biofilms in patients with chronic wounds. 
 
Laboratory:  760 Biomedical Research Tower, 614-688-1619

Personnel
 

Kassem-Ali Abbas

Undergraduate

abbas.42@osu.edu

Mohini Bhattacharya

Graduate Student

mohini.bhattacharya@osumc.edu

Sarah Chaney

Research Associate

chaney.128@osu.edu

Heather Eggleston

Graduate Student

eggleston.24@osu.edu

​Anthony English ​Undergraduate ​english.205@osu.edu

Erin Gloag

Postdoctoral Researcher

gloag.1@osu.edu

​Nikolas Grotewold ​Undergraduate grotewold.4@osu.edu​
​Jacob Harris ​Undergraduate ​harris.2390@osu.edu

Preston Hill

Research Assistant

preston.hill@osumc.edu

Christopher Jones​

Postdoctoral Researcher

christophe​r.jones@osumc.edu

​Ronit Majumdar ​Undergraduate ​majumdar.21@osu.edu

Sankalp Malhotra

Graduate Student

malhotra.58@osu.edu

Mona Nolan

Research Associate

dellos-nolan.1@osu.edu

Matt Pestrak

Graduate Student

pestrak.1@osu.edu

Valerie Ray

Postdoctoral Researcher

valerie.ray@osumc.edu

​Kari Watts ​Undergraduate ​​watts.338@osu.edu
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